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Rabbit Polyclonal Phospho-p47-phox (S345) antibody (STJ90988)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for p47-phox (phospho Ser345) Polyclonal Antibody.
Check alternative names for the antibodyExpand
NCF1 antibody, NOXO2 antibody, SH3PXD1A antibody,|47 kDa autosomal chronic granulomatous disease protein antibody|47 kDa neutrophil oxidase factor antibody|NADPH oxidase organizer 2 antibody|NCF 47K antibody|NCF-1 antibody|NCF-47K antibody|Ncf1 antibody|NCF1_HUMAN antibody|Neutrophil cytosol factor 1 antibody|Neutrophil cytosolic factor 1 antibody|neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1) antibody|Neutrophil NADPH oxidase factor 1 antibody|Nox organizer 2 antibody|Nox organizing protein 2 antibody|Nox-organizing protein 2 antibody|NOXO2 antibody|p47 phox antibody|p47-phox antibody|SH3 and PX domain containing protein 1A antibody|SH3 and PX domain-containing protein 1A antibody|SH3PXD1A antibody|Anti-NCF1 antibody (ab795)
SCBT cat No: sc-17844|sc-7660|sc-17845|sc-23492|sc-14015|
p47-phox (phospho Ser345) Polyclonal Antibody
|Catalogue No.|| |
Phospho-p47-phox (S345) Polyclonal Antibody detects endogenous levels of p47-phox protein only when phosphorylated at S345.
Synthesized phospho-peptide derived from p47-phox (phospho Ser345) at AA range 280-360
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
p47-phox (phospho Ser345) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
p47-phox (phospho Ser345) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Neutrophil cytosol factor 1 antibody, NCF-1 antibody, 47 kDa autosomal chronic granulomatous disease protein antibody, 47 kDa neutrophil oxidase factor antibody, NCF-47K antibody, Neutrophil NADPH oxidase factor 1 antibody, Nox organizer 2 antibody, Nox-organizing protein 2 antibody, SH3 and PX domain-containing protein 1A antibody, p47-phox antibody
|Protein names|| |
Neutrophil cytosol factor 1 , NCF-1 , 47 kDa autosomal chronic granulomatous disease protein , 47 kDa neutrophil oxidase factor , NCF-47K , Neutrophil NADPH oxidase factor 1 , Nox organizer 2 , Nox-organizing protein 2 , SH3 and PX domain-containing protein 1A , p47-phox
|Protein function|| |
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
|Protein tissue specificity|| |
Detected in peripheral blood monocytes and neutrophils (at protein level).
|Involvement in disease|| |
Granulomatous disease, chronic, cytochrome-b-positive 1, autosomal recessive (CGD1) [MIM:233700]: A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The PX domain mediates interaction with phosphatidylinositol 3,4-bisphosphate and other anionic phospholipids. In the autoinhibited, unphosphorylated state an intramolecular interaction with the C-terminal SH3 domain precludes phospholipid binding and interaction with CYBA. Phosphorylation disrupts the autoinhibited state. / Contains 1 PX (phox homology) domain. / Contains 2 SH3 domains.
|Protein post-translational modifications|| |
Phosphorylated by PRKCD; phosphorylation induces activation of NCF1 and NADPH oxidase activity.
|Protein cellular localization|| |
Cytoplasm > cytosol / Membrane / Peripheral membrane protein / Cytoplasmic side
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St John’s Laboratory Ltd.
|Product type|| |
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