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Rabbit Polyclonal Phospho-p73 (Y99) antibody (STJ90378)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for p73 (phospho Tyr99) Polyclonal Antibody.
Check alternative names for the antibodyExpand
TP73 antibody, P73 antibody,|p53 like transcription factor antibody|p53-like transcription factor antibody|p73 antibody|P73_HUMAN antibody|TP73 antibody|Tumor protein p73 antibody|Anti-p73 antibody [EP436Y] (ab40658)
SCBT cat No: sc-56086|sc-70966|sc-23429|sc-517013|sc-14190|sc-28281|sc-14187|sc-517236|sc-10473|sc-10471|sc-15373|sc-14194|
p73 (phospho Tyr99) Polyclonal Antibody
|Catalogue No.|| |
Phospho-p73 (Y99) Polyclonal Antibody detects endogenous levels of p73 protein only when phosphorylated at Y99.
Synthesized phospho-peptide derived from p73 (phospho Tyr99) at AA range 40-120
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
p73 (phospho Tyr99) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
p73 (phospho Tyr99) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tumor protein p73 antibody, p53-like transcription factor antibody, p53-related protein antibody
|Protein names|| |
Tumor protein p73 , p53-like transcription factor , p53-related protein
|Protein function|| |
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. / Zn2+
|Protein tissue specificity|| |
Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue.
|Protein sequence and domain|| |
Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL1 tyrosine kinase SH3 domain. / The WW-binding motif mediates interaction with WWOX. / Belongs to the p53 family. / Contains 1 SAM (sterile alpha motif) domain.
|Protein post-translational modifications|| |
Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function. / Higher levels of phosphorylation seen in the brain from patients with Huntington disease. / Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome.
|Protein cellular localization|| |
Nucleus / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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