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Rabbit Polyclonal Phospho-PAK5/6 (S602/S560) antibody (STJ90635)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for PAK5/6 (phospho Ser602/S560) Polyclonal Antibody.
Check alternative names for the antibodyExpand
PAK7 antibody, KIAA1264 antibody, PAK5 antibody,|PAK4 antibody| PAK7 antibody|KIAA1142 antibody|KIAA126 antibody|p21-activated kinase 4 antibody|p21-activated kinase 5 antibody|p21-activated kinase 6 antibody|p21-activated kinase 7 antibody|PAK-4 antibody|PAK-5 antibody|PAK-6 antibody|PAK5 antibody|PAK6 antibody|Serine/threonine-protein kinase PAK 4 antibody|Serine/threonine-protein kinase PAK 6 antibody|Serine/threonine-protein kinase PAK 7 antibody|Phospho anti-PAK4 + PAK5 + PAK6 (S474 + S560 + S602) antibody [EPR2471(2)] (ab134097)
SCBT cat No: sc-393102|sc-32857|sc-393075|sc-25975|
PAK5/6 (phospho Ser602/S560) Polyclonal Antibody
|Catalogue No.|| |
Phospho-PAK5/6 (S602/S560) Polyclonal Antibody detects endogenous levels of PAK5/6 protein only when phosphorylated at S602/S560.
Synthesized phospho-peptide derived from PAK5/6 (phospho Ser602/S560) at AA range 540-620
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
PAK5/6 (phospho Ser602/S560) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PAK5/6 (phospho Ser602/S560) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Serine/threonine-protein kinase PAK 7 antibody, p21-activated kinase 5 antibody, PAK-5 antibody, p21-activated kinase 7 antibody, PAK-7 antibody
|Protein names|| |
Serine/threonine-protein kinase PAK 7 , p21-activated kinase 5 , PAK-5 , p21-activated kinase 7 , PAK-7
|Protein function|| |
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. / ATP + a protein = ADP + a phosphoprotein.
|Protein tissue specificity|| |
Predominantly expressed in brain.
|Protein sequence and domain|| |
An autoinhibitory domain is present in the N-terminal region of the protein. / Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. / Contains 1 CRIB domain. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Autophosphorylated when activated by CDC42/p21.
|Protein cellular localization|| |
Mitochondrion / Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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