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Rabbit Polyclonal Phospho-PAKbeta (S154) antibody (STJ90955)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for PAKbeta (phospho Ser154) Polyclonal Antibody.
Check alternative names for the antibodyExpand
PAK3 antibody, OPHN3 antibody,|Alpha PAK antibody|P58 antibody|P65 PAK antibody|PAK 2 antibody|PAK 3 antibody|PAK1 antibody|PAK2 antibody|PAK3 antibody|PAK3beta antibody|PAK65 antibody|PAKalpha antibody|PAKgamma antibody|S6/H4 kinase antibody|Serine/threonine protein kinase PAK 1 antibody|Serine/threonine protein kinase PAK 2 antibody|Serine/threonine protein kinase PAK 3 antibody|Serine/threonine protein kinase PAK1 antibody|Serine/threonine protein kinase PAK2 antibody|Serine/threonine protein kinase PAK3 antibody|STE20 homolog, yeast antibody|Phospho anti-PAK1 + PAK2 + PAK3 (S141) antibody (ab5247)
SCBT cat No: sc-882|sc-50693|sc-50694|sc-293362|sc-10925|sc-10927|sc-161294|
PAKbeta (phospho Ser154) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-PAKbeta (S154) Polyclonal Antibody detects endogenous levels of PAKbeta protein only when phosphorylated at S154.
Synthesized phospho-peptide derived from PAKbeta (phospho Ser154) at AA range 90-170
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
|Molecular weight|| |
PAKbeta (phospho Ser154) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PAKbeta (phospho Ser154) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Serine/threonine-protein kinase PAK 3 antibody, Beta-PAK antibody, Oligophrenin-3 antibody, p21-activated kinase 3 antibody, PAK-3 antibody
|Protein names|| |
Serine/threonine-protein kinase PAK 3 , Beta-PAK , Oligophrenin-3 , p21-activated kinase 3 , PAK-3
|Protein function|| |
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. / ATP + a protein = ADP + a phosphoprotein. / Mg2+ / Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-436 and allows the kinase domain to adopt an active structure (By similarity).
|Protein tissue specificity|| |
Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
|Involvement in disease|| |
Mental retardation, X-linked 30 (MRX30) [MIM:300558]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. / Contains 1 CRIB domain. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Autophosphorylated when activated by CDC42/p21. / Neddylated.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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