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Rabbit Polyclonal Phospho-Paxillin (Y88) antibody (STJ90381)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Paxillin (phospho Tyr88) Polyclonal Antibody.
Check alternative names for the antibodyExpand
PXN antibody,|FLJ16691 antibody|FLJ23042 antibody|Paired box protein Pax 1 antibody|PAX 1 antibody|PAX1 antibody|PAXI_HUMAN antibody|Paxillin alpha antibody|Paxillin antibody|PXN antibody|PXN protein antibody|Anti-Paxillin antibody [Y113] (ab32084)
SCBT cat No: sc-136297|sc-390738|sc-365379|sc-373880|sc-393149|sc-7336|sc-365059|sc-365174|sc-5574|sc-31009|sc-31008|sc-31010|sc-390095|sc-367222|sc-166932|sc-271963|
Paxillin (phospho Tyr88) Polyclonal Antibody
|Catalogue No.|| |
Phospho-Paxillin (Y88) Polyclonal Antibody detects endogenous levels of Paxillin protein only when phosphorylated at Y88.
Synthesized phospho-peptide derived from human Paxillin around the phosphorylation site of Y88
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
Paxillin (phospho Tyr88) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Paxillin (phospho Tyr88) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
|Protein names|| |
|Protein function|| |
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
|Protein sequence and domain|| |
Belongs to the paxillin family. / Contains 4 LIM zinc-binding domains.
|Protein post-translational modifications|| |
Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility .
|Protein cellular localization|| |
Cytoplasm > cytoskeleton / Cell junction > focal adhesion / Cytoplasm > cell cortex
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St John’s Laboratory Ltd.
|Product type|| |
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