Rabbit Polyclonal Phospho-Pdcd-4 (S457) antibody (STJ90921)


Reactivity: Human, Mouse, Rat
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Pdcd-4 (S457) antibody (STJ90921)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Pdcd-4 (phospho Ser457) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody


PDCD4 antibody, H731 antibody,|Death up-regulated gene protein antibody|Dug antibody|H731 antibody|Ma3 antibody|MGC33046 antibody|MGC33047 antibody|Neoplastic transformation inhibitor antibody|Neoplastic transformation inhibitor protein antibody|Nuclear antigen H731 antibody|Nuclear antigen H731 like antibody|Nuclear antigen H731 like protein antibody|Nuclear antigen H731-like antibody|PDCD 4 antibody|Pdcd4 antibody|PDCD4_HUMAN antibody|Programmed cell death 4 antibody|programmed cell death 4 (neoplastic transformation inhibitor) antibody|Programmed cell death protein 4 antibody|Protein 197/15a antibody|Protein MA-3 antibody|Tis antibody|Topoisomerase-inhibitor suppressed protein antibody|Anti-PDCD4 antibody (ab51495)
SCBT cat No: sc-376430|sc-27123|sc-292504|sc-130545|



Pdcd-4 (phospho Ser457) Polyclonal Antibody

Catalogue No.



Human, Mouse, Rat


Phospho-Pdcd-4 (S457) Polyclonal Antibody detects endogenous levels of Pdcd-4 protein only when phosphorylated at S457.


Synthesized phospho-peptide derived from Pdcd-4 (phospho Ser457) at AA range 400-480





Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;







Molecular weight

51 kDa


Pdcd-4 (phospho Ser457) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.


1 mg/ml


Pdcd-4 (phospho Ser457) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Programmed cell death protein 4 antibody, Neoplastic transformation inhibitor protein antibody, Nuclear antigen H731-like antibody, Protein 197/15a antibody

Database links

Human UniProt/Swiss-Prot:Q53EL6;Mouse UniPort/Swiss-Prot: Q61823;Rat UniProt/Swiss-Port: Q9JID1;Human Entrez Gene: 27250;Mouse Entrez Gene: 18569;Rat Entrez Gene: Rn.122017

Protein names

Programmed cell death protein 4 , Neoplastic transformation inhibitor protein , Nuclear antigen H731-like , Protein 197/15a

Protein function

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).

Protein tissue specificity

Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.

Protein sequence and domain

Binds EIF4A1 via both MI domains. / Belongs to the PDCD4 family. / Contains 2 MI domains.

Protein post-translational modifications

Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation. / Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.

Protein cellular localization

Nucleus / Cytoplasm

Research area

All research areas>Tumor Suppressor/Apoptosis>Programmed Cell Death
(View all antibody categories related to Tumor Suppressor/Apoptosis)


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St John’s Laboratory Ltd.

Product type

Primary antibody


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