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Rabbit Polyclonal Phospho-Pdcd-4 (S67) antibody (STJ90547)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Pdcd-4 (phospho Ser67) Polyclonal Antibody.
Check alternative names for the antibodyExpand
PDCD4 antibody, H731 antibody,|Death up-regulated gene protein antibody|Dug antibody|H731 antibody|Ma3 antibody|MGC33046 antibody|MGC33047 antibody|Neoplastic transformation inhibitor antibody|Neoplastic transformation inhibitor protein antibody|Nuclear antigen H731 antibody|Nuclear antigen H731 like antibody|Nuclear antigen H731 like protein antibody|Nuclear antigen H731-like antibody|PDCD 4 antibody|Pdcd4 antibody|PDCD4_HUMAN antibody|Programmed cell death 4 antibody|programmed cell death 4 (neoplastic transformation inhibitor) antibody|Programmed cell death protein 4 antibody|Protein 197/15a antibody|Protein MA-3 antibody|Tis antibody|Topoisomerase-inhibitor suppressed protein antibody|Anti-PDCD4 antibody (ab51495)
SCBT cat No: sc-376430|sc-27123|sc-292504|sc-130545|
Pdcd-4 (phospho Ser67) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Monkey
Phospho-Pdcd-4 (S67) Polyclonal Antibody detects endogenous levels of Pdcd-4 protein only when phosphorylated at S67.
Synthesized phospho-peptide derived from Pdcd-4 (phospho Ser67) at AA range 10-90
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
Pdcd-4 (phospho Ser67) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Pdcd-4 (phospho Ser67) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Programmed cell death protein 4 antibody, Neoplastic transformation inhibitor protein antibody, Nuclear antigen H731-like antibody, Protein 197/15a antibody
|Protein names|| |
Programmed cell death protein 4 , Neoplastic transformation inhibitor protein , Nuclear antigen H731-like , Protein 197/15a
|Protein function|| |
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
|Protein tissue specificity|| |
Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
|Protein sequence and domain|| |
Binds EIF4A1 via both MI domains. / Belongs to the PDCD4 family. / Contains 2 MI domains.
|Protein post-translational modifications|| |
Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation. / Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.
|Protein cellular localization|| |
Nucleus / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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