Rabbit Polyclonal Phospho-PIK3R1/PIK3R2/PIK3R3-Y467 antibody (AP0427)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-PIK3R1/PIK3R2/PIK3R3-Y467 antibody (AP0427)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:1000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PI3-kinase p85 subunit alpha antibody; PtdIns-3-kinase p85-alpha antibody;
GRB 1 antibody|GRB1 antibody|p85 alpha antibody|p85 antibody|P85A_HUMAN antibody|Phosphatidylinositol 3 kinase associated p 85 alpha antibody|Phosphatidylinositol 3 kinase regulatory 1 antibody|Phosphatidylinositol 3 kinase regulatory subunit alpha antibody|Phosphatidylinositol 3 kinase regulatory subunit polypeptide 1 (p85 alpha) antibody|Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha antibody|Phosphatidylinositol 3-kinase regulatory subunit alpha antibody|Phosphoinositide 3 kinase regulatory subunit 1 (alpha) antibody|Phosphoinositide 3 kinase regulatory subunit 1 (p85 alpha) antibody|Phosphoinositide 3 kinase regulatory subunit 1 antibody|Phosphoinositide 3 kinase regulatory subunit polypeptide 1 (p85 alpha) antibody|PI3 kinase p85 subunit alpha antibody|PI3-kinase regulatory subunit alpha antibody|PI3-kinase subunit p85-alpha antibody|PI3K antibody|PI3K regulatory subunit alpha antibody|Pik3r1 antibody|PtdIns 3 kinase p85 alpha antibody|PtdIns-3-kinase regulatory subunit alpha antibody|PtdIns-3-kinase regulatory subunit p85-alpha antibody|Anti-PI3K p85 antibody [M253] (ab86714)

SCBT cat No: sc-71891|sc-71892|sc-1637|sc-376112|sc-377482|sc-31969|sc-31970|sc-56938|sc-423|sc-374534|sc-292114|

Name

Rabbit Polyclonal Phospho-PIK3R1/PIK3R2/PIK3R3-Y467 antibody

Catalogue No.

AP0427

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding Y467 of human PIK3R1/2/3

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

85kDa

Formulation

Phospho-PIK3R1/PIK3R2/PIK3R3-Y467 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PI3-kinase p85 subunit alpha antibody; PtdIns-3-kinase p85-alpha antibody;

Protein names

PI3-kinase p85 subunit alpha ; PtdIns-3-kinase p85-alpha;

Protein function

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).

Protein tissue specificity

Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).

Protein sequence and domain

Belongs to the PI3K p85 subunit family.; Contains 1 Rho-GAP domain.; Contains 2 SH2 domains.; Contains 1 SH3 domain. The SH3 domain mediates the binding to CBLB, and to HIV-1 Nef.

Protein post-translational modifications

Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.; Phosphorylated. Tyrosine phosphorylated in response to signaling by FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated by CSF1R. Phosphorylated by ERBB4. Phosphorylated on tyrosine residues by TEK/TIE2. Dephosphorylated by PTPRJ. Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF. The relevance of phosphorylation by PIK3CA is however unclear (By similarity). Phosphorylated in response to KIT and KITLG/SCF. Phosphorylated by FGR.

Background

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1./Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Kinases-and-Phosphatases/">Kinases and Phosphatases</a>><a href="http://antibodyplus.com/product-tag/PI-3-kinase/">PI 3-kinase</a><br><a href="http://antibodyplus.com/product-tag/Kinases-and-Phosphatases/"&gt; (View all antibody categories related to Kinases and Phosphatases)</a>

Note

AntibodyPlus can customize Phospho-PIK3R1/PIK3R2/PIK3R3-Y467 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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