Rabbit Polyclonal Phospho-PKM2-S37 antibody (AP0428)

$99.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-PKM2-S37 antibody (AP0428)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:1000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PKM2 antibody; TCB antibody; PK3 antibody; PKM2 pyruvate kinase antibody; muscle antibody; CTHBP antibody; PK2 antibody;
Pyruvate kinase 3 antibody|CTHBP antibody|Cytosolic thyroid hormone-binding protein antibody|epididymis secretory protein Li 30 antibody|HEL-S-30 antibody|OIP3 antibody|OPA interacting protein 3 antibody|p58 antibody|PK, muscle type antibody|PK1 antibody|PK2 antibody|PKL antibody|PKLR antibody|PKM 2 antibody|PKM antibody|PKM2 antibody|PYKM antibody|Pyruvate kinase 1 antibody|Pyruvate kinase 2/3 antibody|Pyruvate kinase isozyme R/L antibody|pyruvate kinase isozymes L/R antibody|Pyruvate kinase isozymes M1/M2 antibody|pyruvate kinase isozymes R/L antibody|Pyruvate kinase liver and blood cell antibody|Pyruvate kinase liver and RBC antibody|Pyruvate kinase muscle antibody|Pyruvate kinase muscle isozyme antibody|pyruvate kinase PKM antibody|pyruvate kinase type L antibody|Pyruvate kinase, liver and red blood cell antibody|Pyruvate kinase, liver type antibody|Pyruvate kinase, muscle, 2 antibody|Pyruvate kinase, red cell type antibody|R type/L type pyruvate kinase antibody|Red cell/liver pyruvate kinase antibody|RPK antibody|TCB antibody|THBP1 antibody|Thyroid hormone binding protein cytosolic antibody|thyroid hormone-binding protein 1 antibody|tumor M2-PK antibody|Anti-Pyruvate Kinase antibody (ab118499)

SCBT cat No: sc-365684|sc-65176|sc-292640|sc-135048|sc-100538|

Name

Rabbit Polyclonal Phospho-PKM2-S37 antibody

Catalogue No.

AP0428

Reactivity

Human

Immunogen

A phospho specific peptide corresponding to residues surrounding S37 of human PKM2

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

60kDa

Formulation

Phospho-PKM2-S37 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PKM2 antibody; TCB antibody; PK3 antibody; PKM2 pyruvate kinase antibody; muscle antibody; CTHBP antibody; PK2 antibody;

Protein names

PKM2 ; TCB; PK3; PKM2 pyruvate kinase; muscle; CTHBP; PK2;

Protein function

Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Protein tissue specificity

Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells.

Protein sequence and domain

Belongs to the pyruvate kinase family.

Protein post-translational modifications

ISGylated.; Under hypoxia, hydroxylated by EGLN3.; Acetylation at Lys-305 is stimulated by high glucose concentration, it decreases enzyme activity and promotes its lysosomal-dependent degradation via chaperone-mediated autophagy.; FGFR1-dependent tyrosine phosphorylation is reduced by interaction with TRIM35.

Protein cellular localization

Cytoplasm . Nucleus. Note=Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic activity.

Background

Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Synthesis-and-Degradation/">Synthesis and Degradation</a>><a href="http://antibodyplus.com/product-tag/PKM2/">PKM2</a><br><a href="http://antibodyplus.com/product-tag/Synthesis-and-Degradation/"&gt; (View all antibody categories related to Synthesis and Degradation)</a>

Note

AntibodyPlus can customize Phospho-PKM2-S37 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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