Rabbit Polyclonal Phospho-PLC gamma1 (Y1253) antibody (STJ90475)


Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-PLC gamma1 (Y1253) antibody (STJ90475)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for PLC gamma1 (phospho Tyr1253) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody


PLCG1 antibody, PLC1 antibody,|1 phosphatidyl D myo inositol 4 5 bisphosphate antibody|1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 1 antibody|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 antibody|Inositoltrisphosphohydrolase antibody|Monophosphatidylinositol phosphodiesterase antibody|NCKAP3 antibody|Phosphatidylinositol phospholipase C antibody|Phosphoinositidase C antibody|Phosphoinositide phospholipase C antibody|Phosphoinositide phospholipase C-gamma-1 antibody|Phospholipase C 148 antibody|Phospholipase C gamma 1 antibody|Phospholipase C-gamma-1 antibody|Phospholipase C-II antibody|PLC gamma 1 antibody|PLC II antibody|PLC-148 antibody|PLC-gamma-1 antibody|PLC-II antibody|PLC1 antibody|PLC148 antibody|Plcg1 antibody|PLCG1_HUMAN antibody|PLCgamma1 antibody|Anti-Phospholipase C gamma 1 antibody [2B1] (ab16955)
SCBT cat No: sc-81|sc-58407|sc-426|sc-374467|sc-7290|sc-166938|sc-31748|sc-390389|sc-5283|sc-9015|sc-407|sc-131752|



PLC gamma1 (phospho Tyr1253) Polyclonal Antibody

Catalogue No.



Human, Mouse, Rat


Phospho-PLC gamma1 (Y1253) Polyclonal Antibody detects endogenous levels of PLC gamma1 protein only when phosphorylated at Y1253.


Synthesized phospho-peptide derived from PLC gamma1 (phospho Tyr1253) at AA range 1190-1270





Recommended dilution

WB 1:500-1:2000; ELISA 1:20000;







Molecular weight

150 kDa


PLC gamma1 (phospho Tyr1253) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.


1 mg/ml


PLC gamma1 (phospho Tyr1253) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 antibody, PLC-148 antibody, Phosphoinositide phospholipase C-gamma-1 antibody, Phospholipase C-II antibody, PLC-II antibody, Phospholipase C-gamma-1 antibody, PLC-gamma-1 antibody

Database links

Human UniProt/Swiss-Prot:P19174;Mouse UniPort/Swiss-Prot: Q62077;Rat UniProt/Swiss-Port: P10686;Human Entrez Gene: 5335;Mouse Entrez Gene: 18803;Rat Entrez Gene: Rn.11243

Protein names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 , PLC-148 , Phosphoinositide phospholipase C-gamma-1 , Phospholipase C-II , PLC-II , Phospholipase C-gamma-1 , PLC-gamma-1

Protein function

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. / 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. / Ca2+ / Activated by phosphorylation on tyrosine residues.

Protein sequence and domain

The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction with RALGPS1. / Contains 1 C2 domain. / Contains 1 EF-hand domain. / Contains 2 PH domains. / Contains 1 PI-PLC X-box domain. / Contains 1 PI-PLC Y-box domain. / Contains 2 SH2 domains. / Contains 1 SH3 domain.

Protein post-translational modifications

Tyrosine phosphorylated in response to signaling via activated FLT3, KIT and PDGFRA (By similarity). Tyrosine phosphorylated by activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylated by activated FLT1 and KDR. Tyrosine phosphorylated by activated PDGFRB. The receptor-mediated activation of PLCG1 involves its phosphorylation by tyrosine kinases, in response to ligation of a variety of growth factor receptors and immune system receptors. For instance, SYK phosphorylates and activates PLCG1 in response to ligation of the B-cell receptor. May be dephosphorylated by PTPRJ. Phosphorylated by ITK and TXK on Tyr-783 upon TCR activation in T-cells. / Ubiquitinated by CBLB in activated T-cells.

Protein cellular localization

Cell projection > lamellipodium / Cell projection > ruffle

Research area

All research areas>Synthesis and Degradation>PLC
(View all antibody categories related to Synthesis and Degradation)


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St John’s Laboratory Ltd.

Product type

Primary antibody


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