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Rabbit Polyclonal Phospho-PLC gamma2 (Y1217) antibody (STJ91048)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for PLC gamma2 (phospho Tyr1217) Polyclonal Antibody.
Check alternative names for the antibodyExpand
PLCG2 antibody,|1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 2 antibody|1-phosphatidylinositol-4 antibody|5-bisphosphate phosphodiesterase gamma-2 antibody|EC 22.214.171.124 antibody|Phosphoinositide phospholipase C antibody|Phosphoinositide phospholipase C-gamma-2 antibody|Phospholipase C gamma 2 antibody|Phospholipase C, gamma 2 (phosphatidylinositol specific) antibody|Phospholipase C-gamma-2 antibody|Phospholipase C-IV antibody|PLC 2 antibody|PLC gamma 2 antibody|PLC IV antibody|PLC-gamma-2 antibody|PLC-IV antibody|Plcg2 antibody|PLCG2_HUMAN antibody|Phospho anti-PLCG 2 (Y753) antibody (ab75659)
SCBT cat No: sc-390389|sc-5283|sc-9015|sc-407|sc-131752|
PLC gamma2 (phospho Tyr1217) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-PLC gamma2 (Y1217) Polyclonal Antibody detects endogenous levels of PLC gamma2 protein only when phosphorylated at Y1217.
Synthesized phospho-peptide derived from PLC gamma2 (phospho Tyr1217) at AA range 1160-1240
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;
|Molecular weight|| |
PLC gamma2 (phospho Tyr1217) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PLC gamma2 (phospho Tyr1217) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 antibody, Phosphoinositide phospholipase C-gamma-2 antibody, Phospholipase C-IV antibody, PLC-IV antibody, Phospholipase C-gamma-2 antibody, PLC-gamma-2 antibody
|Protein names|| |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 , Phosphoinositide phospholipase C-gamma-2 , Phospholipase C-IV , PLC-IV , Phospholipase C-gamma-2 , PLC-gamma-2
|Protein function|| |
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. / 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. / Ca2+
|Involvement in disease|| |
Familial cold autoinflammatory syndrome 3 (FCAS3) [MIM:614468]: An autosomal dominant immune disorder characterized by the development of cutaneous urticaria, erythema, and pruritis in response to cold exposure. Affected individuals have variable additional immunologic defects, including antibody deficiency, decreased numbers of B-cells, defective B-cells, increased susceptibility to infection, and increased risk of autoimmune disorders. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Autoinflammation, antibody deficiency, and immune dysregulation PLCG2-associated (APLAID) [MIM:614878]: An autosomal dominant systemic disorder characterized by recurrent blistering skin lesions with a dense inflammatory infiltrate and variable involvement of other tissues, including joints, the eye, and the gastrointestinal tract. Affected individuals have a mild humoral immune deficiency associated with recurrent sinopulmonary infections, but no evidence of circulating autoantibodies. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 1 C2 domain. / Contains 1 PH domain. / Contains 1 PI-PLC X-box domain. / Contains 1 PI-PLC Y-box domain. / Contains 2 SH2 domains. / Contains 1 SH3 domain.
|Protein post-translational modifications|| |
Phosphorylated on tyrosine residues by CSF1R (By similarity). Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity.
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St John’s Laboratory Ltd.
|Product type|| |
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