Rabbit Polyclonal Phospho-PLC gamma2 (Y753) antibody (STJ90768)

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Reactivity: Human, Mouse, Rat
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-PLC gamma2 (Y753) antibody (STJ90768)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for PLC gamma2 (phospho Tyr753) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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PLCG2 antibody,|1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 2 antibody|1-phosphatidylinositol-4 antibody|5-bisphosphate phosphodiesterase gamma-2 antibody|EC 3.1.4.11 antibody|Phosphoinositide phospholipase C antibody|Phosphoinositide phospholipase C-gamma-2 antibody|Phospholipase C gamma 2 antibody|Phospholipase C, gamma 2 (phosphatidylinositol specific) antibody|Phospholipase C-gamma-2 antibody|Phospholipase C-IV antibody|PLC 2 antibody|PLC gamma 2 antibody|PLC IV antibody|PLC-gamma-2 antibody|PLC-IV antibody|Plcg2 antibody|PLCG2_HUMAN antibody|Phospho anti-PLCG 2 (Y753) antibody (ab75659)
SCBT cat No: sc-390389|sc-5283|sc-9015|sc-407|sc-131752|

 

Name

PLC gamma2 (phospho Tyr753) Polyclonal Antibody

Catalogue No.

STJ90768

Reactivity

Human, Mouse, Rat

Specificity

Phospho-PLC gamma2 (Y753) Polyclonal Antibody detects endogenous levels of PLC gamma2 protein only when phosphorylated at Y753.

Immunogen

Synthesized phospho-peptide derived from PLC gamma2 (phospho Tyr753) at AA range 690-770

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

148 kDa

Formulation

PLC gamma2 (phospho Tyr753) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

PLC gamma2 (phospho Tyr753) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 antibody, Phosphoinositide phospholipase C-gamma-2 antibody, Phospholipase C-IV antibody, PLC-IV antibody, Phospholipase C-gamma-2 antibody, PLC-gamma-2 antibody

Database links

Human UniProt/Swiss-Prot:P16885;Mouse UniPort/Swiss-Prot: Q8CIH5;Rat UniProt/Swiss-Port: P24135;Human Entrez Gene: 5336;Mouse Entrez Gene: 234779;Rat Entrez Gene: Rn.9751

Protein names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 , Phosphoinositide phospholipase C-gamma-2 , Phospholipase C-IV , PLC-IV , Phospholipase C-gamma-2 , PLC-gamma-2

Protein function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. / 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. / Ca2+

Involvement in disease

Familial cold autoinflammatory syndrome 3 (FCAS3) [MIM:614468]: An autosomal dominant immune disorder characterized by the development of cutaneous urticaria, erythema, and pruritis in response to cold exposure. Affected individuals have variable additional immunologic defects, including antibody deficiency, decreased numbers of B-cells, defective B-cells, increased susceptibility to infection, and increased risk of autoimmune disorders. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Autoinflammation, antibody deficiency, and immune dysregulation PLCG2-associated (APLAID) [MIM:614878]: An autosomal dominant systemic disorder characterized by recurrent blistering skin lesions with a dense inflammatory infiltrate and variable involvement of other tissues, including joints, the eye, and the gastrointestinal tract. Affected individuals have a mild humoral immune deficiency associated with recurrent sinopulmonary infections, but no evidence of circulating autoantibodies. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Contains 1 C2 domain. / Contains 1 PH domain. / Contains 1 PI-PLC X-box domain. / Contains 1 PI-PLC Y-box domain. / Contains 2 SH2 domains. / Contains 1 SH3 domain.

Protein post-translational modifications

Phosphorylated on tyrosine residues by CSF1R (By similarity). Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity.

Research area

All research areas>Synthesis and Degradation>PLC gamma 2
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize PLC gamma2 (phospho Tyr753) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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