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Rabbit Polyclonal Phospho-PP2A-Calpha (Y307) antibody (STJ91049)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
PPP2CA antibody,|PP2A alpha antibody|PP2A-alpha antibody|PP2AA_HUMAN antibody|PP2Aalpha antibody|PP2Ac antibody|PP2CA antibody|PP2Calpha antibody|PPP2CA antibody|Protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform antibody|Protein phosphatase 2 catalytic subunit alpha isoform antibody|Protein phosphatase 2, catalytic subunit, alpha isozyme antibody|Protein phosphatase 2A catalytic subunit, alpha isoform antibody|Replication protein C antibody|RP C antibody|RP-C antibody|RPC antibody|Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform antibody|Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform antibody|Anti-PP2A-alpha antibody (ab137825)
SCBT cat No: sc-13601|sc-80990|sc-167616|sc-138914|sc-246424|sc-398374|sc-390685|sc-87080|sc-160276|sc-514660|sc-246432|
PP2A-Calpha (phospho Tyr307) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-PP2A-Calpha (Y307) Polyclonal Antibody detects endogenous levels of PP2A-Calpha protein only when phosphorylated at Y307.
Synthesized phospho-peptide derived from PP2A-Calpha (phospho Tyr307) at AA range 250-330
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;
|Molecular weight|| |
PP2A-Calpha (phospho Tyr307) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PP2A-Calpha (phospho Tyr307) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform antibody, PP2A-alpha antibody, Replication protein C antibody, RP-C antibody
|Protein names|| |
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform , PP2A-alpha , Replication protein C , RP-C
|Protein function|| |
PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at ‘Ser-259’. / [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate. / Mn2+
|Protein sequence and domain|| |
Belongs to the PPP phosphatase family. PP-1 subfamily.
|Protein post-translational modifications|| |
Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme’s substrate specificity, enzyme activity and cellular localization. / Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation. / May be monoubiquitinated by NOSIP.
|Protein cellular localization|| |
Cytoplasm / Nucleus / Chromosome > centromere / Cytoplasm > cytoskeleton > spindle pole
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St John’s Laboratory Ltd.
|Product type|| |
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