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Rabbit Polyclonal Phospho-Presenilin 1 (S357) antibody (STJ90991)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for Presenilin 1 (phospho Ser357) Polyclonal Antibody.
Check alternative names for the antibodyExpand
PSEN1 antibody, AD3 antibody, PS1 antibody, PSNL1 antibody,|AD3 antibody|Ad3h antibody|FAD antibody|Homo Sapiens Clone CC44 Senilin 1 antibody|Presenilin-1 CTF12 antibody|Protein S182 antibody|PS 1 antibody|PS-1 antibody|PS1-CTF12 antibody|PSEN1 antibody|PSN1_HUMAN antibody|PSNL1 antibody|S182 antibody|Anti-Presenilin 1 antibody [APS 11] (ab15456)
SCBT cat No: sc-16795|sc-12891|sc-130604|sc-377573|sc-101787|sc-31714|
Presenilin 1 (phospho Ser357) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Presenilin 1 (S357) Polyclonal Antibody detects endogenous levels of Presenilin 1 protein only when phosphorylated at S357.
Synthesized phospho-peptide derived from Presenilin 1 (phospho Ser357) at AA range 300-380
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
Presenilin 1 (phospho Ser357) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Presenilin 1 (phospho Ser357) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Presenilin-1 antibody, PS-1 antibody, Protein S182 antibody
|Protein names|| |
Presenilin-1 , PS-1 , Protein S182
|Protein function|| |
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
|Protein tissue specificity|| |
Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes.
|Involvement in disease|| |
Alzheimer disease 3 (AD3) [MIM:607822]: A familial early-onset form of Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Frontotemporal dementia (FTD) [MIM:600274]: A form of dementia characterized by pathologic finding of frontotemporal lobar degeneration, presenile dementia with behavioral changes, deterioration of cognitive capacities and loss of memory. In some cases, parkinsonian symptoms are prominent. Neuropathological changes include frontotemporal atrophy often associated with atrophy of the basal ganglia, substantia nigra, amygdala. In most cases, protein tau deposits are found in glial cells and/or neurons. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Cardiomyopathy, dilated 1U (CMD1U) [MIM:613694]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Acne inversa, familial, 3 (ACNINV3) [MIM:613737]: A chronic relapsing inflammatory disease of the hair follicles characterized by recurrent draining sinuses, painful skin abscesses, and disfiguring scars. Manifestations typically appear after puberty. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The PAL motif is required for normal active site conformation. / Belongs to the peptidase A22A family.
|Protein post-translational modifications|| |
Heterogeneous proteolytic processing generates N-terminal (NTF) and C-terminal (CTF) fragments of approximately 35 and 20 kDa, respectively. During apoptosis, the C-terminal fragment (CTF) is further cleaved by caspase-3 to produce the fragment, PS1-CTF12. / After endoproteolysis, the C-terminal fragment (CTF) is phosphorylated on serine residues by PKA and/or PKC. Phosphorylation on Ser-346 inhibits endoproteolysis.
|Protein cellular localization|| |
Endoplasmic reticulum membrane; Multi-pass membrane protein / Golgi apparatus membrane; Multi-pass membrane protein / Cell surface / Cell membrane
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St John’s Laboratory Ltd.
|Product type|| |
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