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Rabbit Polyclonal Phospho-PTP1B (S50) antibody (STJ90882)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
Recommended protocols: check protocols
Click or hover above images to see image description for PTP1B (phospho Ser50) Polyclonal Antibody.
Check alternative names for the antibodyExpand
PTPN1 antibody, PTP1B antibody,|PTP1B antibody|Non receptor tyrosine phosphatase 1 antibody|Protein phosphotyrosylphosphatase 1B antibody|Protein tyrosine phosphatase 1B antibody|Protein tyrosine phosphatase non receptor type 1 antibody|Protein tyrosine phosphatase placental antibody|Protein-tyrosine phosphatase 1B antibody|PTN1_HUMAN antibody|PTP 1B antibody|PTP-1B antibody|PTPN 1 antibody|PTPN1 antibody|Tyrosine protein phosphatase non receptor type 1 antibody|Tyrosine-protein phosphatase non-receptor type 1 antibody|Anti-PTP1B antibody [4F8F11] (ab201974)
SCBT cat No: sc-56960|sc-133115|sc-1719|sc-133259|sc-14021|sc-133258|sc-1718|
PTP1B (phospho Ser50) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Monkey
Phospho-PTP1B (S50) Polyclonal Antibody detects endogenous levels of PTP1B protein only when phosphorylated at S50.
Synthesized phospho-peptide derived from PTP1B (phospho Ser50) at AA range 30-110
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
|Molecular weight|| |
PTP1B (phospho Ser50) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PTP1B (phospho Ser50) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tyrosine-protein phosphatase non-receptor type 1 antibody, Protein-tyrosine phosphatase 1B antibody, PTP-1B antibody
|Protein names|| |
Tyrosine-protein phosphatase non-receptor type 1 , Protein-tyrosine phosphatase 1B , PTP-1B
|Protein function|| |
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. / Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
|Protein sequence and domain|| |
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. / Contains 1 tyrosine-protein phosphatase domain.
|Protein post-translational modifications|| |
Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a sulfenamide cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction. / Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50. / S-nitrosylation of Cys-215 inactivates the enzyme activity. / Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity.
|Protein cellular localization|| |
Endoplasmic reticulum membrane / Peripheral membrane protein / Cytoplasmic side
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St John’s Laboratory Ltd.
|Product type|| |
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