Rabbit Polyclonal Phospho-PTP1B (S50) antibody (STJ90882)

$99.00$319.00

Reactivity: Human, Mouse, Rat, Monkey
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-PTP1B (S50) antibody (STJ90882)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for PTP1B (phospho Ser50) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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PTPN1 antibody, PTP1B antibody,|PTP1B antibody|Non receptor tyrosine phosphatase 1 antibody|Protein phosphotyrosylphosphatase 1B antibody|Protein tyrosine phosphatase 1B antibody|Protein tyrosine phosphatase non receptor type 1 antibody|Protein tyrosine phosphatase placental antibody|Protein-tyrosine phosphatase 1B antibody|PTN1_HUMAN antibody|PTP 1B antibody|PTP-1B antibody|PTPN 1 antibody|PTPN1 antibody|Tyrosine protein phosphatase non receptor type 1 antibody|Tyrosine-protein phosphatase non-receptor type 1 antibody|Anti-PTP1B antibody [4F8F11] (ab201974)
SCBT cat No: sc-56960|sc-133115|sc-1719|sc-133259|sc-14021|sc-133258|sc-1718|

 

Name

PTP1B (phospho Ser50) Polyclonal Antibody

Catalogue No.

STJ90882

Reactivity

Human, Mouse, Rat, Monkey

Specificity

Phospho-PTP1B (S50) Polyclonal Antibody detects endogenous levels of PTP1B protein only when phosphorylated at S50.

Immunogen

Synthesized phospho-peptide derived from PTP1B (phospho Ser50) at AA range 30-110

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

49 kDa

Formulation

PTP1B (phospho Ser50) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

PTP1B (phospho Ser50) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Tyrosine-protein phosphatase non-receptor type 1 antibody, Protein-tyrosine phosphatase 1B antibody, PTP-1B antibody

Database links

Human UniProt/Swiss-Prot:P18031;Mouse UniPort/Swiss-Prot: P35821;Rat UniProt/Swiss-Port: P20417;Human Entrez Gene: 5770;Mouse Entrez Gene: 19246;Rat Entrez Gene: Rn.11317

Protein names

Tyrosine-protein phosphatase non-receptor type 1 , Protein-tyrosine phosphatase 1B , PTP-1B

Protein function

Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. / Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Protein sequence and domain

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. / Contains 1 tyrosine-protein phosphatase domain.

Protein post-translational modifications

Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a sulfenamide cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction. / Ser-50 is the major site of phosphorylation as compared to Ser-242 and Ser-243. Activated by phosphorylation at Ser-50. / S-nitrosylation of Cys-215 inactivates the enzyme activity. / Sulfhydration at Cys-215 following endoplasmic reticulum stress inactivates the enzyme activity, promoting EIF2AK3/PERK activity.

Protein cellular localization

Endoplasmic reticulum membrane / Peripheral membrane protein / Cytoplasmic side

Research area

All research areas>Kinases and Phosphatases>PTP
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize PTP1B (phospho Ser50) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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