Rabbit Polyclonal Phospho-PTPN11-Y580 antibody (AP0439)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-PTPN11-Y580 antibody (AP0439)

Supplier: ABclonal Inc.

Recommended applications: IHC

Recommended dilution:

IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal Phospho-PTPN11-Y580 antibody.

Alternative names:

Check alternative names for the antibody

Expand

CFC antibody; NS1 antibody; SHP2 antibody; BPTP3 antibody; PTP2C antibody; PTP-1D antibody; SH-PTP2 antibody; SH-PTP3 antibody;
BPTP3 antibody|CFC antibody|JMML antibody|METCDS antibody|MGC14433 antibody|NS1 antibody|OTTHUMP00000166107 antibody|OTTHUMP00000166108 antibody|Protein tyrosine phosphatase 2 antibody|Protein tyrosine phosphatase 2C antibody|Protein tyrosine phosphatase non receptor type 11 antibody|Protein-tyrosine phosphatase 1D antibody|Protein-tyrosine phosphatase 2C antibody|PTN11_HUMAN antibody|PTP-1D antibody|PTP-2C antibody|PTP1D antibody|PTP2C antibody|PTPN11 antibody|SAP2 antibody|SH-PTP2 antibody|SH-PTP3 antibody|SH2 domain containing protein tyrosine phosphatase 2 antibody|SHP 2 antibody|SHP-2 antibody|Shp2 antibody|SHPTP2 antibody|SHPTP3 antibody|Syp antibody|Tyrosine-protein phosphatase non-receptor type 11 antibody|Anti-SHP2 antibody [Y478] (ab32083)

SCBT cat No: sc-293147|sc-101798|sc-101799|sc-136227|sc-101087|sc-33371|sc-136094|sc-130857|sc-514401|sc-10269|

Name

Rabbit Polyclonal Phospho-PTPN11-Y580 antibody

Catalogue No.

AP0439

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding Y580 of human PTPN11

Host

Rabbit

Applications

IHC

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

72kDa

Formulation

Phospho-PTPN11-Y580 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CFC antibody; NS1 antibody; SHP2 antibody; BPTP3 antibody; PTP2C antibody; PTP-1D antibody; SH-PTP2 antibody; SH-PTP3 antibody;

Protein names

CFC; NS1; SHP2; BPTP3; PTP2C; PTP-1D; SH-PTP2; SH-PTP3;

Protein function

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).

Protein tissue specificity

Widely expressed, with highest levels in heart, brain, and skeletal muscle.

Protein sequence and domain

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.; Contains 2 SH2 domains.; Contains 1 tyrosine-protein phosphatase domain. The SH2 domains repress phosphatase activity. Binding of these domains to phosphotyrosine-containing proteins relieves this auto-inhibition, possibly by inducing a conformational change in the enzyme.

Protein post-translational modifications

Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.

Protein cellular localization

Cytoplasm . Nucleus .

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Kinases-and-Phosphatases/">Kinases and Phosphatases</a>><a href="http://antibodyplus.com/product-tag/SH-PTP/">SH-PTP</a><br><a href="http://antibodyplus.com/product-tag/Kinases-and-Phosphatases/"&gt; (View all antibody categories related to Kinases and Phosphatases)</a>

Note

AntibodyPlus can customize Phospho-PTPN11-Y580 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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