Rabbit Polyclonal Phospho-PTPN11-Y580 antibody (AP0439)


Reactivity: Human,Mouse,Rat
Applications: IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-PTPN11-Y580 antibody (AP0439)

Supplier: ABclonal Inc.

Recommended applications: IHC

Recommended dilution:

IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal Phospho-PTPN11-Y580 antibody.

Alternative names:

Check alternative names for the antibody


CFC antibody; NS1 antibody; SHP2 antibody; BPTP3 antibody; PTP2C antibody; PTP-1D antibody; SH-PTP2 antibody; SH-PTP3 antibody;
BPTP3 antibody|CFC antibody|JMML antibody|METCDS antibody|MGC14433 antibody|NS1 antibody|OTTHUMP00000166107 antibody|OTTHUMP00000166108 antibody|Protein tyrosine phosphatase 2 antibody|Protein tyrosine phosphatase 2C antibody|Protein tyrosine phosphatase non receptor type 11 antibody|Protein-tyrosine phosphatase 1D antibody|Protein-tyrosine phosphatase 2C antibody|PTN11_HUMAN antibody|PTP-1D antibody|PTP-2C antibody|PTP1D antibody|PTP2C antibody|PTPN11 antibody|SAP2 antibody|SH-PTP2 antibody|SH-PTP3 antibody|SH2 domain containing protein tyrosine phosphatase 2 antibody|SHP 2 antibody|SHP-2 antibody|Shp2 antibody|SHPTP2 antibody|SHPTP3 antibody|Syp antibody|Tyrosine-protein phosphatase non-receptor type 11 antibody|Anti-SHP2 antibody [Y478] (ab32083)

SCBT cat No: sc-293147|sc-101798|sc-101799|sc-136227|sc-101087|sc-33371|sc-136094|sc-130857|sc-514401|sc-10269|


Rabbit Polyclonal Phospho-PTPN11-Y580 antibody

Catalogue No.



Human, Mouse, Rat


A phospho specific peptide corresponding to residues surrounding Y580 of human PTPN11











Molecular weight



Phospho-PTPN11-Y580 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.


Affinity purification


Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CFC antibody; NS1 antibody; SHP2 antibody; BPTP3 antibody; PTP2C antibody; PTP-1D antibody; SH-PTP2 antibody; SH-PTP3 antibody;

Protein names


Protein function

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).

Protein tissue specificity

Widely expressed, with highest levels in heart, brain, and skeletal muscle.

Protein sequence and domain

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.; Contains 2 SH2 domains.; Contains 1 tyrosine-protein phosphatase domain. The SH2 domains repress phosphatase activity. Binding of these domains to phosphotyrosine-containing proteins relieves this auto-inhibition, possibly by inducing a conformational change in the enzyme.

Protein post-translational modifications

Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.

Protein cellular localization

Cytoplasm . Nucleus .


The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Kinases-and-Phosphatases/">Kinases and Phosphatases</a>><a href="http://antibodyplus.com/product-tag/SH-PTP/">SH-PTP</a><br><a href="http://antibodyplus.com/product-tag/Kinases-and-Phosphatases/"&gt; (View all antibody categories related to Kinases and Phosphatases)</a>


AntibodyPlus can customize Phospho-PTPN11-Y580 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody


ABclonal Inc.


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