Rabbit Polyclonal Phospho-PTPN6-Y536 antibody (AP0440)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-PTPN6-Y536 antibody (AP0440)

Supplier: ABclonal Inc.

Recommended applications: IHC,IF

Recommended dilution:

IHC 1:50 – 1:100
IF 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal Phospho-PTPN6-Y536 antibody.

Alternative names:

Check alternative names for the antibody

Expand

HCP antibody; HCPH antibody; SHP1 antibody; SHP-1 antibody; HPTP1C antibody; PTP-1C antibody; SHP-1L antibody; SH-PTP1 antibody;
70Z-SHP antibody|EC 3.1.3.48 antibody|HCP antibody|HCPH antibody|Hematopoietic cell phosphatase antibody|Hematopoietic cell protein tyrosine phosphatase antibody|Hematopoietic cell protein-tyrosine phosphatase antibody|HPTP1C antibody|Protein tyrosine phosphatase 1C antibody|Protein tyrosine phosphatase non receptor type 6 antibody|Protein tyrosine phosphatase SHP1 antibody|Protein-tyrosine phosphatase 1C antibody|protein-tyrosine phosphatase SHP 1 antibody|Protein-tyrosine phosphatase SHP-1 antibody|PTN6_HUMAN antibody|PTP 1C antibody|PTP-1C antibody|PTP1C antibody|Ptpn6 antibody|SH PTP 1 antibody|SH PTP1 antibody|SH-PTP1 antibody|SHP 1 antibody|SHP 1L antibody|SHP1 antibody|SHP1L antibody|tyrosine protein phosphatase non receptor type 6 antibody|Tyrosine-protein phosphatase non-receptor type 6 antibody|Anti-SHP1 antibody [Y476] (ab32559)

SCBT cat No: sc-135780|sc-135781|sc-135782|sc-293147|sc-101798|sc-101799|sc-136227|sc-101087|sc-33371|sc-136094|sc-130857|

Name

Rabbit Polyclonal Phospho-PTPN6-Y536 antibody

Catalogue No.

AP0440

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding Y536 of human PTPN6

Host

Rabbit

Applications

IHC, IF

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

68kDa

Formulation

Phospho-PTPN6-Y536 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HCP antibody; HCPH antibody; SHP1 antibody; SHP-1 antibody; HPTP1C antibody; PTP-1C antibody; SHP-1L antibody; SH-PTP1 antibody;

Protein names

HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1;

Protein function

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

Protein tissue specificity

Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.

Protein sequence and domain

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.; Contains 2 SH2 domains.; Contains 1 tyrosine-protein phosphatase domain. The N-terminal SH2 domain functions as an auto-inhibitory domain, blocking the catalytic domain in the ligand-free close conformation.

Protein post-translational modifications

Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 enhances phosphatase activity.

Protein cellular localization

Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1.

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Kinases-and-Phosphatases/">Kinases and Phosphatases</a>><a href="http://antibodyplus.com/product-tag/SH-PTP/">SH-PTP</a><br><a href="http://antibodyplus.com/product-tag/Kinases-and-Phosphatases/"&gt; (View all antibody categories related to Kinases and Phosphatases)</a>

Note

AntibodyPlus can customize Phospho-PTPN6-Y536 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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