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Rabbit Polyclonal Phospho-Rad17 (S645) antibody (STJ90451)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for Rad17 (phospho Ser645) Polyclonal Antibody.
Check alternative names for the antibodyExpand
RAD17 antibody, R24L antibody,|CCYC antibody|Cell cycle checkpoint protein antibody|Cell cycle checkpoint protein RAD17 antibody|FLJ41520 antibody|HRAD 17 antibody|hRad17 antibody|R24L antibody|Rad 17 antibody|Rad 24 antibody|RAD1 (S. pombe) homolog antibody|RAD1 homolog antibody|RAD17 antibody|RAD17 homolog (S. pombe) antibody|RAD17 homolog antibody|Rad17 like protein antibody|RAD17, S. pombe, homolog of antibody|RAD17_HUMAN antibody|RAD17Sp antibody|Rad24 antibody|Rad24, mouse, homolog of antibody|Rad24, S. cerevisiae, homolog of antibody|RF C activator 1 homolog antibody|RF C/activator 1 homolog antibody|RF-C/activator 1 homolog antibody|Phospho anti-Rad17 (S645) antibody (ab3620)
SCBT cat No: sc-32842|sc-32843|sc-81513|sc-271929|sc-271928|
Rad17 (phospho Ser645) Polyclonal Antibody
|Catalogue No.|| |
Phospho-Rad17 (S645) Polyclonal Antibody detects endogenous levels of Rad17 protein only when phosphorylated at S645.
Synthesized phospho-peptide derived from Rad17 (phospho Ser645) at AA range 590-670
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:5000;
|Molecular weight|| |
Rad17 (phospho Ser645) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Rad17 (phospho Ser645) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Cell cycle checkpoint protein RAD17 antibody, hRad17 antibody, RF-C/activator 1 homolog antibody
|Protein names|| |
Cell cycle checkpoint protein RAD17 , hRad17 , RF-C/activator 1 homolog
|Protein function|| |
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
|Protein tissue specificity|| |
Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors).
|Protein sequence and domain|| |
Belongs to the rad17/RAD24 family.
|Protein post-translational modifications|| |
Phosphorylated. Phosphorylation on Ser-646 and Ser-656 is cell cycle-regulated, enhanced by genotoxic stress, and required for activation of checkpoint signaling. Phosphorylation is mediated by ATR upon UV or replication arrest, whereas it may be mediated both by ATR and ATM upon ionizing radiation. Phosphorylation on both sites is required for interaction with RAD1 but dispensable for interaction with RFC3 or RFC4.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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