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Rabbit Polyclonal Phospho-Rad51 (Y315) antibody (STJ90536)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Rad51 (phospho Tyr315) Polyclonal Antibody.
Check alternative names for the antibodyExpand
RAD51 antibody, RAD51A antibody, RECA antibody,|BRCA1/BRCA2 containing complex, subunit 5 antibody|BRCC 5 antibody|BRCC5 antibody|DNA repair protein RAD51 homolog 1 antibody|DNA repair protein rhp51 antibody|hRAD51 antibody|HsRAD51 antibody|HsT16930 antibody|MRMV2 antibody|Rad 51 antibody|RAD51 antibody|RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) antibody|RAD51 homolog A antibody|RAD51 homolog antibody|RAD51 recombinase antibody|RAD51, S. cerevisiae, homolog of antibody|RAD51_HUMAN antibody|RAD51A antibody|RECA antibody|RecA like protein antibody|RecA, E. coli, homolog of antibody|Recombination protein A antibody|Anti-Rad51 antibody (ab88572)
SCBT cat No: sc-53428|sc-56212|sc-6862|sc-398587|sc-377467|sc-8349|sc-56469|
Rad51 (phospho Tyr315) Polyclonal Antibody
|Catalogue No.|| |
Phospho-Rad51 (Y315) Polyclonal Antibody detects endogenous levels of Rad51 protein only when phosphorylated at Y315.
Synthesized phospho-peptide derived from Rad51 (phospho Tyr315) at AA range 250-330
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
Rad51 (phospho Tyr315) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Rad51 (phospho Tyr315) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
DNA repair protein RAD51 homolog 1 antibody, HsRAD51 antibody, hRAD51 antibody, RAD51 homolog A antibody
|Protein names|| |
DNA repair protein RAD51 homolog 1 , HsRAD51 , hRAD51 , RAD51 homolog A
|Protein function|| |
Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.
|Protein tissue specificity|| |
Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.
|Involvement in disease|| |
Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Mirror movements 2 (MRMV2) [MIM:614508]: A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Note: Defects in RAD51 are found in a patient with microcephaly, mental retardation without bone marrow failure and pediatric cancers.
|Protein sequence and domain|| |
The nuclear localization may reside in the C-terminus (between 259 and 339 AA). / Belongs to the RecA family. RAD51 subfamily. / Contains 1 HhH domain.
|Protein post-translational modifications|| |
Ubiquitinated by the SCF(FBXO18) E3 ubiquitin ligase complex, regulating RAD51 subcellular location and preventing its association with DNA. / Phosphorylated. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylation by ABL1 inhibits function.
|Protein cellular localization|| |
Nucleus / Cytoplasm / Cytoplasm > perinuclear region / Mitochondrion matrix / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome
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St John’s Laboratory Ltd.
|Product type|| |
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