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Rabbit Polyclonal Phospho-RelB (S552) antibody (STJ91004)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for RelB (phospho Ser552) Polyclonal Antibody.
Check alternative names for the antibodyExpand
RELB antibody,|I REL antibody|I-Rel antibody|IREL antibody|Nuclear factor of kappa light polypeptide gene enhancer in B cells 3 antibody|relB antibody|RELB_HUMAN antibody|Reticuloendotheliosis viral oncogene homolog B antibody|Transcription factor Rel B antibody|Transcription factor RelB antibody|v rel avian reticuloendotheliosis viral oncogene homolog B antibody|v rel reticuloendotheliosis viral oncogene homolog B antibody|Anti-Rel B antibody [EPR7076] – C-terminal (ab180127)
SCBT cat No: sc-101792|sc-390191|sc-100817|sc-366193|sc-160082|sc-365416|sc-98504|sc-82324|sc-25282|sc-55471|
RelB (phospho Ser552) Polyclonal Antibody
|Catalogue No.|| |
Phospho-RelB (S552) Polyclonal Antibody detects endogenous levels of RelB protein only when phosphorylated at S552.
Synthesized phospho-peptide derived from RelB (phospho Ser552) at AA range 510-590
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
|Molecular weight|| |
RelB (phospho Ser552) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
RelB (phospho Ser552) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Transcription factor RelB antibody, I-Rel antibody
|Protein names|| |
Transcription factor RelB , I-Rel
|Protein function|| |
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52.
|Protein tissue specificity|| |
Up-regulated by mitogens and NUPR1.
|Protein sequence and domain|| |
Both N- and C-terminal domains are required for transcriptional activation. / Contains 1 RHD (Rel-like) domain.
|Protein post-translational modifications|| |
Phosphorylation at ‘Thr-103’ and ‘Ser-573’ is followed by proteasomal degradation.
|Protein cellular localization|| |
Nucleus / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome
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St John’s Laboratory Ltd.
|Product type|| |
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