Rabbit Polyclonal Phospho-RelB (S552) antibody (STJ91004)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-RelB (S552) antibody (STJ91004)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for RelB (phospho Ser552) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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RELB antibody,|I REL antibody|I-Rel antibody|IREL antibody|Nuclear factor of kappa light polypeptide gene enhancer in B cells 3 antibody|relB antibody|RELB_HUMAN antibody|Reticuloendotheliosis viral oncogene homolog B antibody|Transcription factor Rel B antibody|Transcription factor RelB antibody|v rel avian reticuloendotheliosis viral oncogene homolog B antibody|v rel reticuloendotheliosis viral oncogene homolog B antibody|Anti-Rel B antibody [EPR7076] – C-terminal (ab180127)
SCBT cat No: sc-101792|sc-390191|sc-100817|sc-366193|sc-160082|sc-365416|sc-98504|sc-82324|sc-25282|sc-55471|

 

Name

RelB (phospho Ser552) Polyclonal Antibody

Catalogue No.

STJ91004

Reactivity

Human, Mouse

Specificity

Phospho-RelB (S552) Polyclonal Antibody detects endogenous levels of RelB protein only when phosphorylated at S552.

Immunogen

Synthesized phospho-peptide derived from RelB (phospho Ser552) at AA range 510-590

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

70/62 kDa

Formulation

RelB (phospho Ser552) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

RelB (phospho Ser552) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Transcription factor RelB antibody, I-Rel antibody

Database links

Human UniProt/Swiss-Prot:Q01201;Mouse UniPort/Swiss-Prot: Q04863;Human Entrez Gene: 5971;Mouse Entrez Gene: 19698;

Protein names

Transcription factor RelB , I-Rel

Protein function

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52.

Protein tissue specificity

Up-regulated by mitogens and NUPR1.

Protein sequence and domain

Both N- and C-terminal domains are required for transcriptional activation. / Contains 1 RHD (Rel-like) domain.

Protein post-translational modifications

Phosphorylation at ‘Thr-103’ and ‘Ser-573’ is followed by proteasomal degradation.

Protein cellular localization

Nucleus / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome

Research area

All research areas>Transcription Regulators>RelB
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize RelB (phospho Ser552) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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