Rabbit Polyclonal Phospho-RELB-S573 antibody (AP0240)

$99.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-RELB-S573 antibody (AP0240)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal Phospho-RELB-S573 antibody.

Alternative names:

Check alternative names for the antibody

Expand

IREL antibody; I-REL antibody; REL-B antibody;
I REL antibody|I-Rel antibody|IREL antibody|Nuclear factor of kappa light polypeptide gene enhancer in B cells 3 antibody|relB antibody|RELB_HUMAN antibody|Reticuloendotheliosis viral oncogene homolog B antibody|Transcription factor Rel B antibody|Transcription factor RelB antibody|v rel avian reticuloendotheliosis viral oncogene homolog B antibody|v rel reticuloendotheliosis viral oncogene homolog B antibody|Anti-Rel B antibody [EPR7076] – C-terminal (ab180127)

SCBT cat No: sc-101792|sc-390191|sc-100817|sc-366193|sc-160082|sc-365416|sc-98504|sc-82324|sc-25282|sc-55471|

Name

Rabbit Polyclonal Phospho-RELB-S573 antibody

Catalogue No.

AP0240

Reactivity

Human, Mouse

Immunogen

A phospho specific peptide corresponding to residues surrounding S573 of human RELB

Host

Rabbit

Applications

WB, IHC

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

70kDa

Formulation

Phospho-RELB-S573 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

IREL antibody; I-REL antibody; REL-B antibody;

Protein names

IREL; I-REL; REL-B;

Protein function

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52.

Protein sequence and domain

Contains 1 RHD (Rel-like) domain. Both N- and C-terminal domains are required for transcriptional activation.

Protein post-translational modifications

Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation.

Protein cellular localization

Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Note=Colocalizes with NEK6 in the centrosome.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Transcription-Regulators/">Transcription Regulators</a>><a href="http://antibodyplus.com/product-tag/RelB/">RelB</a><br><a href="http://antibodyplus.com/product-tag/Transcription-Regulators/"&gt; (View all antibody categories related to Transcription Regulators)</a>

Note

AntibodyPlus can customize Phospho-RELB-S573 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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