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Rabbit Polyclonal Phospho-RIP2 (S176) antibody (STJ90957)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
Recommended protocols: check protocols
Click or hover above images to see image description for RIP2 (phospho Ser176) Polyclonal Antibody.
Check alternative names for the antibodyExpand
RIPK2 antibody, CARDIAK antibody, RICK antibody, RIP2 antibody, UNQ277/PRO314/PRO34092 antibody,|CARD 3 antibody|CARD carrying kinase antibody|CARD containing ICE associated kinase antibody|CARD containing IL 1 beta ICE kinase antibody|CARD containing IL1 beta ICE kinase antibody|CARD containing interleukin 1 beta converting enzyme (ICE) associated kinase antibody|CARD containing interleukin 1 beta converting enzyme associated kinase antibody|CARD-containing IL-1 beta ICE-kinase antibody|CARD-containing interleukin-1 beta-converting enzyme-associated kinase antibody|CARD3 antibody|CARDIAK antibody|CCK antibody|CLARP kinase antibody|GIG 30 antibody|GIG30 antibody|Growth inhibiting gene 30 antibody|Receptor interacting protein (RIP) like interacting caspase like apoptosis regulatory protein (CLARP) kinase antibody|Receptor interacting protein 2 antibody|Receptor interacting serine threonine kinase 2 antibody|Receptor interacting serine/threonine protein kinase 2 antibody|Receptor-interacting protein 2 antibody|Receptor-interacting serine/threonine-protein kinase 2 antibody|RICK antibody|RIP 2 antibody|RIP like interacting CLARP kinase antibody|RIP-2 antibody|RIP-like-interacting CLARP kinase antibody|RIPK 2 antibody|Ripk2 antibody|RIPK2_HUMAN antibody|TNFRSF antibody|Tyrosine-protein kinase RIPK2 antibody|UNQ277/PRO314/PRO34092 antibody|Anti-RIP2 antibody (ab8428)
SCBT cat No: sc-136059|sc-166765|sc-22763|sc-8610|
RIP2 (phospho Ser176) Polyclonal Antibody
|Catalogue No.|| |
Phospho-RIP2 (S176) Polyclonal Antibody detects endogenous levels of RIP2 protein only when phosphorylated at S176.
Synthesized phospho-peptide derived from RIP2 (phospho Ser176) at AA range 120-200
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
|Molecular weight|| |
RIP2 (phospho Ser176) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
RIP2 (phospho Ser176) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Receptor-interacting serine/threonine-protein kinase 2 antibody, CARD-containing interleukin-1 beta-converting enzyme-associated kinase antibody, CARD-containing IL-1 beta ICE-kinase antibody, RIP-like-interacting CLARP kinase antibody, Receptor-interacting protein 2 antibody, RIP-2 antibody, Tyrosine-protein kinase RIPK2 antibody,
|Protein names|| |
Receptor-interacting serine/threonine-protein kinase 2 , CARD-containing interleukin-1 beta-converting enzyme-associated kinase , CARD-containing IL-1 beta ICE-kinase , RIP-like-interacting CLARP kinase , Receptor-interacting protein 2 , RIP-2 , Tyrosine-protein kinase RIPK2 ,
|Protein function|| |
Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes ‘Lys-63’-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces ‘Lys-63’-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation. / ATP + a protein = ADP + a phosphoprotein. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
|Protein tissue specificity|| |
Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
|Protein sequence and domain|| |
Contains an N-terminal kinase domain and a C-terminal caspase activation and recruitment domain (CARD) that mediates the recruitment of CARD-containing proteins. / Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. / Contains 1 CARD domain. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Autophosphorylated. Autophosphorylation at Tyr-474 is necessary for effective NOD2 signaling. Phosphorylated. Phosphorylation at Tyr-381 by Src kinase CSK occurs in a ARHGEF2-dependent manner and is required for NOD2-dependent innate immune activation. / Ubiquitinated on Lys-209; undergoes ‘Lys-63’-linked polyubiquitination catalyzed by ITCH. Polyubiquitinated with ‘Lys-48’ and ‘Lys-63’-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B. Also undergoes ‘Met-1’-linked polyubiquitination; the head-to-tail linear polyubiquitination is mediated by the LUBAC complex in response to NOD2 stimulation. Linear polyubiquitination is restricted by FAM105B/otulin, probably to limit NOD2-dependent proinflammatory signaling activation of NF-kappa-B.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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