Rabbit Polyclonal Phospho-Rsk-1/2/3/4 (S221/227/S218/232) antibody (STJ90596)

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Reactivity: Human, Mouse
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Rsk-1/2/3/4 (S221/227/S218/232) antibody (STJ90596)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:40000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rsk-1/2/3/4 (phospho Ser221/227/S218/232) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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RPS6KA1 antibody, MAPKAPK1A antibody, RSK1 antibody,|90 kDa ribosomal protein S6 kinase 1 antibody|dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1 antibody|dJ590P13.1 antibody|EC 2.7.11.1 antibody|HU 1 antibody|HU1 antibody|KS6A1_HUMAN antibody|MAP kinase activated protein kinase 1a antibody|MAP kinase-activated protein kinase 1a antibody|MAPK-activated protein kinase 1a antibody|MAPKAP kinase 1a antibody|MAPKAPK-1a antibody|MAPKAPK1A antibody|MGC79981 antibody|Mitogen-activated protein kinase-activated protein kinase 1A antibody|OTTHUMP00000004113 antibody|p90 RSK1 antibody|p90-RSK 1 antibody|p90rsk antibody|p90RSK1 antibody|p90S6K antibody|pp90RSK1 antibody|Ribosomal protein S6 kinase 90kD 1 antibody|Ribosomal protein S6 kinase 90kD polypeptide 1 antibody|Ribosomal protein S6 kinase 90kDa polypeptide 1 antibody|Ribosomal protein S6 kinase alpha 1 antibody|Ribosomal protein S6 kinase alpha-1 antibody|Ribosomal protein S6 kinase polypeptide 1 antibody|Ribosomal S6 kinase 1 antibody|RPS6K1 alpha antibody|rps6ka antibody|Rps6ka1 antibody|RSK 1 antibody|RSK 1 p90 antibody|RSK antibody|RSK-1 antibody|RSK1 antibody|S6K alpha 1 antibody|S6K-alpha-1 antibody|Phospho anti-RSK1 p90 (T359 + S363) antibody [E238] (ab32413)
SCBT cat No: sc-377526|sc-12445|sc-11756|sc-136476|sc-135634|sc-101770|sc-12898|sc-17033|sc-377501|sc-374664|sc-16407|sc-169056|

 

Name

Rsk-1/2/3/4 (phospho Ser221/227/S218/232) Polyclonal Antibody

Catalogue No.

STJ90596

Reactivity

Human, Mouse

Specificity

Phospho-Rsk-1/2/3/4 (S221/227/S218/232) Polyclonal Antibody detects endogenous levels of Rsk-1/2/3/4 protein only when phosphorylated at S221/227/S218/232.

Immunogen

Synthesized phospho-peptide derived from Rsk-1/2/3/4 (phospho Ser221/227/S218/232) at AA range 160-240

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:40000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

85 kDa

Formulation

Rsk-1/2/3/4 (phospho Ser221/227/S218/232) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Rsk-1/2/3/4 (phospho Ser221/227/S218/232) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Ribosomal protein S6 kinase alpha-1 antibody, S6K-alpha-1 antibody, 90 kDa ribosomal protein S6 kinase 1 antibody, p90-RSK 1 antibody, p90RSK1 antibody, p90S6K antibody, MAP kinase-activated protein kinase 1a antibody, MAPK-activated protein kinase 1a antibody, MAPKAP kinase 1a antibody, MAPKAPK-1a antibody, Ribosomal S6 kinase 1 antibody, RSK-1 antibody

Database links

Human UniProt/Swiss-Prot:Q15418 ;Human Entrez Gene: 6195;

Protein names

Ribosomal protein S6 kinase alpha-1 , S6K-alpha-1 , 90 kDa ribosomal protein S6 kinase 1 , p90-RSK 1 , p90RSK1 , p90S6K , MAP kinase-activated protein kinase 1a , MAPK-activated protein kinase 1a , MAPKAP kinase 1a , MAPKAPK-1a , Ribosomal S6 kinase 1 , RSK-1

Protein function

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at ‘Ser-9’ and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at ‘Ser-1798’, which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. / ATP + a protein = ADP + a phosphoprotein. / Mg2+ / Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-573 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-380, allowing binding of PDPK1, which in turn phosphorylates Ser-221 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD.

Protein sequence and domain

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. / Contains 1 AGC-kinase C-terminal domain. / Contains 2 protein kinase domains.

Protein post-translational modifications

Activated by phosphorylation at Ser-221 by PDPK1. Autophosphorylated on Ser-380, as part of the activation process. May be phosphorylated at Thr-359 and Ser-363 by MAPK1/ERK2 and MAPK3/ERK1. / N-terminal myristoylation results in an activated kinase in the absence of added growth factors.

Protein cellular localization

Nucleus / Cytoplasm

Research area

All research areas>Kinases and Phosphatases>Rsk
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize Rsk-1/2/3/4 (phospho Ser221/227/S218/232) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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