Rabbit Polyclonal Phospho-SH-PTP1 (Y536) antibody (STJ90740)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-SH-PTP1 (Y536) antibody (STJ90740)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PTPN6 antibody, HCP antibody, PTP1C antibody,|70Z-SHP antibody|EC 3.1.3.48 antibody|HCP antibody|HCPH antibody|Hematopoietic cell phosphatase antibody|Hematopoietic cell protein tyrosine phosphatase antibody|Hematopoietic cell protein-tyrosine phosphatase antibody|HPTP1C antibody|Protein tyrosine phosphatase 1C antibody|Protein tyrosine phosphatase non receptor type 6 antibody|Protein tyrosine phosphatase SHP1 antibody|Protein-tyrosine phosphatase 1C antibody|protein-tyrosine phosphatase SHP 1 antibody|Protein-tyrosine phosphatase SHP-1 antibody|PTN6_HUMAN antibody|PTP 1C antibody|PTP-1C antibody|PTP1C antibody|Ptpn6 antibody|SH PTP 1 antibody|SH PTP1 antibody|SH-PTP1 antibody|SHP 1 antibody|SHP 1L antibody|SHP1 antibody|SHP1L antibody|tyrosine protein phosphatase non receptor type 6 antibody|Tyrosine-protein phosphatase non-receptor type 6 antibody|Anti-SHP1 antibody [Y476] (ab32559)
SCBT cat No: sc-135780|sc-135781|sc-135782|sc-293147|sc-101798|sc-101799|sc-136227|sc-101087|sc-33371|sc-136094|sc-130857|

 

Name

SH-PTP1 (phospho Tyr536) Polyclonal Antibody

Catalogue No.

STJ90740

Reactivity

Human, Mouse, Rat

Specificity

Phospho-SH-PTP1 (Y536) Polyclonal Antibody detects endogenous levels of SH-PTP1 protein only when phosphorylated at Y536.

Immunogen

Synthesized phospho-peptide derived from SH-PTP1 (phospho Tyr536) at AA range 480-560

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

67 kDa

Formulation

SH-PTP1 (phospho Tyr536) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

SH-PTP1 (phospho Tyr536) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Tyrosine-protein phosphatase non-receptor type 6 antibody, Hematopoietic cell protein-tyrosine phosphatase antibody, Protein-tyrosine phosphatase 1C antibody, PTP-1C antibody, Protein-tyrosine phosphatase SHP-1 antibody, SH-PTP1 antibody

Database links

Human UniProt/Swiss-Prot:P29350;Mouse UniPort/Swiss-Prot: P29351;Rat UniProt/Swiss-Port: P81718;Human Entrez Gene: 5777;Mouse Entrez Gene: 15170;Rat Entrez Gene: Rn.18985

Protein names

Tyrosine-protein phosphatase non-receptor type 6 , Hematopoietic cell protein-tyrosine phosphatase , Protein-tyrosine phosphatase 1C , PTP-1C , Protein-tyrosine phosphatase SHP-1 , SH-PTP1

Protein function

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. / Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Protein tissue specificity

Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.

Protein sequence and domain

The N-terminal SH2 domain functions as an auto-inhibitory domain, blocking the catalytic domain in the ligand-free close conformation. / Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. / Contains 2 SH2 domains. / Contains 1 tyrosine-protein phosphatase domain.

Protein post-translational modifications

Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 enhances phosphatase activity.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Kinases and Phosphatases>SH-PTP
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize SH-PTP1 (phospho Tyr536) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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