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Rabbit Polyclonal Phospho-SH-PTP2 (Y580) antibody (STJ90742)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
Recommended protocols: check protocols
Click or hover above images to see image description for SH-PTP2 (phospho Tyr580) Polyclonal Antibody.
Check alternative names for the antibodyExpand
PTPN11 antibody, PTP2C antibody, SHPTP2 antibody,|BPTP3 antibody|CFC antibody|JMML antibody|METCDS antibody|MGC14433 antibody|NS1 antibody|OTTHUMP00000166107 antibody|OTTHUMP00000166108 antibody|Protein tyrosine phosphatase 2 antibody|Protein tyrosine phosphatase 2C antibody|Protein tyrosine phosphatase non receptor type 11 antibody|Protein-tyrosine phosphatase 1D antibody|Protein-tyrosine phosphatase 2C antibody|PTN11_HUMAN antibody|PTP-1D antibody|PTP-2C antibody|PTP1D antibody|PTP2C antibody|PTPN11 antibody|SAP2 antibody|SH-PTP2 antibody|SH-PTP3 antibody|SH2 domain containing protein tyrosine phosphatase 2 antibody|SHP 2 antibody|SHP-2 antibody|Shp2 antibody|SHPTP2 antibody|SHPTP3 antibody|Syp antibody|Tyrosine-protein phosphatase non-receptor type 11 antibody|Anti-SHP2 antibody [Y478] (ab32083)
SCBT cat No: sc-293147|sc-101798|sc-101799|sc-136227|sc-101087|sc-33371|sc-136094|sc-130857|sc-514401|sc-10269|
SH-PTP2 (phospho Tyr580) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-SH-PTP2 (Y580) Polyclonal Antibody detects endogenous levels of SH-PTP2 protein only when phosphorylated at Y580.
Synthesized phospho-peptide derived from SH-PTP2 (phospho Tyr580) at AA range 520-600
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
|Molecular weight|| |
SH-PTP2 (phospho Tyr580) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
SH-PTP2 (phospho Tyr580) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tyrosine-protein phosphatase non-receptor type 11 antibody, Protein-tyrosine phosphatase 1D antibody, PTP-1D antibody, Protein-tyrosine phosphatase 2C antibody, PTP-2C antibody, SH-PTP2 antibody, SHP-2 antibody, Shp2 antibody, SH-PTP3 antibody
|Protein names|| |
Tyrosine-protein phosphatase non-receptor type 11 , Protein-tyrosine phosphatase 1D , PTP-1D , Protein-tyrosine phosphatase 2C , PTP-2C , SH-PTP2 , SHP-2 , Shp2 , SH-PTP3
|Protein function|| |
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. / Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
|Protein tissue specificity|| |
Widely expressed, with highest levels in heart, brain, and skeletal muscle.
|Involvement in disease|| |
LEOPARD syndrome 1 (LPRD1) [MIM:151100]: A disorder characterized by lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and sensorineural deafness. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Noonan syndrome 1 (NS1) [MIM:163950]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. Some patients with NS1 develop multiple giant cell lesions of the jaw or other bony or soft tissues, which are classified as pigmented villonodular synovitis (PVNS) when occurring in the jaw or joints. . Note: The disease is caused by mutations affecting the gene represented in this entry. Mutations in PTPN11 account for more than 50% of the cases.; Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Metachondromatosis (MC) [MIM:156250]: A skeletal disorder with radiologic features of both multiple exostoses and Ollier disease, characterized by the presence of exostoses, commonly of the bones of the hands and feet, and enchondromas of the metaphyses of long bones and iliac crest. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The SH2 domains repress phosphatase activity. Binding of these domains to phosphotyrosine-containing proteins relieves this auto-inhibition, possibly by inducing a conformational change in the enzyme. / Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. / Contains 2 SH2 domains. / Contains 1 tyrosine-protein phosphatase domain.
|Protein post-translational modifications|| |
Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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