Rabbit Polyclonal Phospho-Shb (Y246) antibody (STJ90405)


Reactivity: Human, Mouse
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Shb (Y246) antibody (STJ90405)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Shb (phospho Tyr246) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody


SHB antibody,|bA3J10.2 antibody|OTTHUMP00000021397 antibody|RP11 3J10.8 antibody|RP113J10.8 antibody|SH2 domain containing adapter protein B antibody|SH2 domain-containing adapter protein B antibody|SHB (Src homology 2 domain containing) adaptor protein B antibody|SHB adaptor protein (a Src homology 2 protein) antibody|SHB adaptor protein antibody|Shb antibody|SHB_HUMAN antibody|Src homology 2 domain containing adaptor protein B antibody|Src homology 2 protein antibody|Anti-SHB antibody [EPR7976] (ab129190)
SCBT cat No: To be updated



Shb (phospho Tyr246) Polyclonal Antibody

Catalogue No.



Human, Mouse


Phospho-Shb (Y246) Polyclonal Antibody detects endogenous levels of Shb protein only when phosphorylated at Y246.


Synthesized phospho-peptide derived from human Shb around the phosphorylation site of Y246





Recommended dilution

WB 1:500-1:2000; ELISA 1:10000;







Molecular weight

55 kDa


Shb (phospho Tyr246) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.


1 mg/ml


Shb (phospho Tyr246) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

SH2 domain-containing adapter protein B antibody

Database links

Human UniProt/Swiss-Prot:Q15464;Mouse UniPort/Swiss-Prot: Q6PD21;Rat UniProt/Swiss-Port: D3ZN31;Human Entrez Gene: 6461;Mouse Entrez Gene: 230126;

Protein names

SH2 domain-containing adapter protein B

Protein function

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.

Protein tissue specificity

Widely expressed.

Protein sequence and domain

The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII. / Contains 1 SH2 domain.

Protein post-translational modifications

Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.

Protein cellular localization

Cytoplasm / Cell membrane; Peripheral membrane protein; Cytoplasmic side

Research area

All research areas>Signaling Intermediates>Shb
(View all antibody categories related to Signaling Intermediates)


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St John’s Laboratory Ltd.

Product type

Primary antibody


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