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Rabbit Polyclonal Phospho-Shb (Y246) antibody (STJ90405)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
SHB antibody,|bA3J10.2 antibody|OTTHUMP00000021397 antibody|RP11 3J10.8 antibody|RP113J10.8 antibody|SH2 domain containing adapter protein B antibody|SH2 domain-containing adapter protein B antibody|SHB (Src homology 2 domain containing) adaptor protein B antibody|SHB adaptor protein (a Src homology 2 protein) antibody|SHB adaptor protein antibody|Shb antibody|SHB_HUMAN antibody|Src homology 2 domain containing adaptor protein B antibody|Src homology 2 protein antibody|Anti-SHB antibody [EPR7976] (ab129190)
SCBT cat No: To be updated
Shb (phospho Tyr246) Polyclonal Antibody
|Catalogue No.|| |
Phospho-Shb (Y246) Polyclonal Antibody detects endogenous levels of Shb protein only when phosphorylated at Y246.
Synthesized phospho-peptide derived from human Shb around the phosphorylation site of Y246
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000;
|Molecular weight|| |
Shb (phospho Tyr246) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Shb (phospho Tyr246) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
SH2 domain-containing adapter protein B antibody
|Protein names|| |
SH2 domain-containing adapter protein B
|Protein function|| |
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
|Protein tissue specificity|| |
|Protein sequence and domain|| |
The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII. / Contains 1 SH2 domain.
|Protein post-translational modifications|| |
Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.
|Protein cellular localization|| |
Cytoplasm / Cell membrane; Peripheral membrane protein; Cytoplasmic side
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St John’s Laboratory Ltd.
|Product type|| |
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