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Rabbit Polyclonal Phospho-SHIP-1 (Y1021) antibody (STJ90494)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:40000;
Recommended protocols: check protocols
Click or hover above images to see image description for SHIP-1 (phospho Tyr1021) Polyclonal Antibody.
Check alternative names for the antibodyExpand
INPP5D antibody, SHIP antibody, SHIP1 antibody,|Inositol polyphosphate 5 phosphatase of 145kDa antibody|4 antibody|5-trisphosphate 5-phosphatase 1 antibody|hp51CN antibody|Inositol polyphosphate 5 phosphatase 145kDa antibody|Inositol polyphosphate 5 phosphatase antibody|Inositol polyphosphate-5-phosphatase of 145 kDa antibody|INPP5D antibody|MGC104855 antibody|MGC142140 antibody|MGC142142 antibody|p150Ship antibody|Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1 antibody|Phosphatidylinositol-3 antibody|SH2 containing inositol phosphatase isoform b antibody|SH2 domain containing inositol 5′ phosphatase 1 antibody|SH2 domain containing inositol phosphatase 1 antibody|SH2 domain-containing inositol phosphatase 1 antibody|SH2 domain-containing inositol-5”-phosphatase 1 antibody|SHIP-1 antibody|SHIP1 antibody|SHIP1_HUMAN antibody|Signaling inositol polyphosphate 5 phosphatase SIP 145 antibody|SIP-145 antibody|SIP145 antibody|Anti-SHIP antibody [EP378Y] (ab45142)
SCBT cat No: To be updated
SHIP-1 (phospho Tyr1021) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-SHIP-1 (Y1021) Polyclonal Antibody detects endogenous levels of SHIP-1 protein only when phosphorylated at Y1021.
Synthesized phospho-peptide derived from SHIP-1 (phospho Tyr1021) at AA range 960-1040
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:40000;
|Molecular weight|| |
SHIP-1 (phospho Tyr1021) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
SHIP-1 (phospho Tyr1021) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 antibody, Inositol polyphosphate-5-phosphatase of 145 kDa antibody, SIP-145 antibody, SH2 domain-containing inositol 5′-phosphatase 1 antibody, SH2 domain-containing inositol phosphatase 1 antibody, SHIP-1 antibody, p150Ship antibody, hp51CN antibody
|Protein names|| |
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 , Inositol polyphosphate-5-phosphatase of 145 kDa , SIP-145 , SH2 domain-containing inositol 5′-phosphatase 1 , SH2 domain-containing inositol phosphatase 1 , SHIP-1 , p150Ship , hp51CN
|Protein function|| |
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. / 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate. / Activated upon translocation to the sites of synthesis of PtdIns(3,4,5)P3 in the membrane.
|Protein tissue specificity|| |
Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells. Levels vary considerably within this compartment. Present in at least 74% of immature CD34+ cells, whereas within the more mature population of CD33+ cells, it is present in only 10% of cells. Present in the majority of T-cells, while it is present in a minority of B-cells (at protein level).
|Protein sequence and domain|| |
The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or PTPN11/SHP-2. It competes with that of GRB2 for binding to phosphorylated SHC1 to inhibit the Ras pathway. It is also required for tyrosine phosphorylation (By similarity). / The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. / Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. / Contains 1 SH2 domain.
|Protein post-translational modifications|| |
Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli such as cytokines, growth factors, antibodies, chemokines, integrin ligands and hypertonic and oxidative stress. Phosphorylated upon IgG receptor FCGR2B-binding.
|Protein cellular localization|| |
Cytoplasm / Cell membrane / Peripheral membrane protein / Membrane raft / Cytoplasm > cytoskeleton / Membrane / Peripheral membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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