Rabbit Polyclonal Phospho-SHIP-1 (Y1021) antibody (STJ90494)

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Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-SHIP-1 (Y1021) antibody (STJ90494)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:40000;

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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INPP5D antibody, SHIP antibody, SHIP1 antibody,|Inositol polyphosphate 5 phosphatase of 145kDa antibody|4 antibody|5-trisphosphate 5-phosphatase 1 antibody|hp51CN antibody|Inositol polyphosphate 5 phosphatase 145kDa antibody|Inositol polyphosphate 5 phosphatase antibody|Inositol polyphosphate-5-phosphatase of 145 kDa antibody|INPP5D antibody|MGC104855 antibody|MGC142140 antibody|MGC142142 antibody|p150Ship antibody|Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1 antibody|Phosphatidylinositol-3 antibody|SH2 containing inositol phosphatase isoform b antibody|SH2 domain containing inositol 5′ phosphatase 1 antibody|SH2 domain containing inositol phosphatase 1 antibody|SH2 domain-containing inositol phosphatase 1 antibody|SH2 domain-containing inositol-5”-phosphatase 1 antibody|SHIP-1 antibody|SHIP1 antibody|SHIP1_HUMAN antibody|Signaling inositol polyphosphate 5 phosphatase SIP 145 antibody|SIP-145 antibody|SIP145 antibody|Anti-SHIP antibody [EP378Y] (ab45142)
SCBT cat No: To be updated

 

Name

SHIP-1 (phospho Tyr1021) Polyclonal Antibody

Catalogue No.

STJ90494

Reactivity

Human, Mouse, Rat

Specificity

Phospho-SHIP-1 (Y1021) Polyclonal Antibody detects endogenous levels of SHIP-1 protein only when phosphorylated at Y1021.

Immunogen

Synthesized phospho-peptide derived from SHIP-1 (phospho Tyr1021) at AA range 960-1040

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:40000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

133 kDa

Formulation

SHIP-1 (phospho Tyr1021) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

SHIP-1 (phospho Tyr1021) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 antibody, Inositol polyphosphate-5-phosphatase of 145 kDa antibody, SIP-145 antibody, SH2 domain-containing inositol 5′-phosphatase 1 antibody, SH2 domain-containing inositol phosphatase 1 antibody, SHIP-1 antibody, p150Ship antibody, hp51CN antibody

Database links

Human UniProt/Swiss-Prot:Q92835;Mouse UniPort/Swiss-Prot: Q9ES52;Rat UniProt/Swiss-Port: P97573;Human Entrez Gene: 3635;Mouse Entrez Gene: 16331;Rat Entrez Gene: Rn.10659

Protein names

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 , Inositol polyphosphate-5-phosphatase of 145 kDa , SIP-145 , SH2 domain-containing inositol 5′-phosphatase 1 , SH2 domain-containing inositol phosphatase 1 , SHIP-1 , p150Ship , hp51CN

Protein function

Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. / 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate. / Activated upon translocation to the sites of synthesis of PtdIns(3,4,5)P3 in the membrane.

Protein tissue specificity

Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells. Levels vary considerably within this compartment. Present in at least 74% of immature CD34+ cells, whereas within the more mature population of CD33+ cells, it is present in only 10% of cells. Present in the majority of T-cells, while it is present in a minority of B-cells (at protein level).

Protein sequence and domain

The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or PTPN11/SHP-2. It competes with that of GRB2 for binding to phosphorylated SHC1 to inhibit the Ras pathway. It is also required for tyrosine phosphorylation (By similarity). / The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. / Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. / Contains 1 SH2 domain.

Protein post-translational modifications

Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli such as cytokines, growth factors, antibodies, chemokines, integrin ligands and hypertonic and oxidative stress. Phosphorylated upon IgG receptor FCGR2B-binding.

Protein cellular localization

Cytoplasm / Cell membrane / Peripheral membrane protein / Membrane raft / Cytoplasm > cytoskeleton / Membrane / Peripheral membrane protein

Research area

All research areas>Kinases and Phosphatases>SHIP
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize SHIP-1 (phospho Tyr1021) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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