Rabbit Polyclonal Phospho-Smad1 (S187) antibody (STJ90904)

$99.00$319.00

Reactivity: Human, Mouse, Monkey
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Smad1 (S187) antibody (STJ90904)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Smad1 (phospho Ser187) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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SMAD1 antibody, BSP1 antibody, MADH1 antibody, MADR1 antibody,|BSP-1 antibody|SMAD 1 antibody|SMAD family member 1 antibody|SMAD mothers against DPP homolog 1 antibody|Smad1 antibody|SMAD1_HUMAN antibody|TGF beta signaling protein 1 antibody|Transforming growth factor-beta-signaling protein 1 antibody|Anti-Smad1 antibody [EP565Y] (ab33902)
SCBT cat No: sc-12353|sc-101801|sc-11769|sc-130218|sc-514317|sc-165305|sc-515132|

 

Name

Smad1 (phospho Ser187) Polyclonal Antibody

Catalogue No.

STJ90904

Reactivity

Human, Mouse, Monkey

Specificity

Phospho-Smad1 (S187) Polyclonal Antibody detects endogenous levels of Smad1 protein only when phosphorylated at S187.

Immunogen

Synthesized phospho-peptide derived from Smad1 (phospho Ser187) at AA range 130-210

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

60/55 kDa

Formulation

Smad1 (phospho Ser187) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Smad1 (phospho Ser187) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Mothers against decapentaplegic homolog 1 antibody, MAD homolog 1 antibody, Mothers against DPP homolog 1 antibody, JV4-1 antibody, Mad-related protein 1 antibody, SMAD family member 1 antibody, SMAD 1 antibody, Smad1 antibody, hSMAD1 antibody, Transforming growth factor-beta-signaling protein 1 antibody, BSP-1 antibody

Database links

Human UniProt/Swiss-Prot:Q15797;Mouse UniPort/Swiss-Prot: P70340;Rat UniProt/Swiss-Port: Q6P7A6;Human Entrez Gene: 4086;Mouse Entrez Gene: 17125;Rat Entrez Gene: Rn.10635

Protein names

Mothers against decapentaplegic homolog 1 , MAD homolog 1 , Mothers against DPP homolog 1 , JV4-1 , Mad-related protein 1 , SMAD family member 1 , SMAD 1 , Smad1 , hSMAD1 , Transforming growth factor-beta-signaling protein 1 , BSP-1

Protein function

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.

Protein tissue specificity

Ubiquitous. Highest expression seen in the heart and skeletal muscle.

Involvement in disease

Note: SMAD1 variants may be associated with susceptibility to pulmonary hypertension, a disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs. .

Protein sequence and domain

The MH2 domain mediates phosphorylation-dependent trimerization through L3 loop binding of phosphoserines in the adjacent subunit. / Belongs to the dwarfin/SMAD family. / Contains 1 MH1 (MAD homology 1) domain. / Contains 1 MH2 (MAD homology 2) domain.

Protein post-translational modifications

Phosphorylation of the C-terminal SVS motif by BMP type 1 receptor kinase activates SMAD1 by promoting dissociation from the receptor and trimerization with SMAD4. / Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading to its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Transcription Regulators>Smad
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Smad1 (phospho Ser187) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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