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Rabbit Polyclonal Phospho-Smad1 (S465) antibody (STJ90743)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Smad1 (phospho Ser465) Polyclonal Antibody.
Check alternative names for the antibodyExpand
SMAD1 antibody, BSP1 antibody, MADH1 antibody, MADR1 antibody,|BSP-1 antibody|SMAD 1 antibody|SMAD family member 1 antibody|SMAD mothers against DPP homolog 1 antibody|Smad1 antibody|SMAD1_HUMAN antibody|TGF beta signaling protein 1 antibody|Transforming growth factor-beta-signaling protein 1 antibody|Anti-Smad1 antibody [EP565Y] (ab33902)
SCBT cat No: sc-12353|sc-101801|sc-11769|sc-130218|sc-514317|sc-165305|sc-515132|
Smad1 (phospho Ser465) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Smad1 (S465) Polyclonal Antibody detects endogenous levels of Smad1 protein only when phosphorylated at S465.
Synthesized phospho-peptide derived from Smad1 (phospho Ser465) at AA range 400-480
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
|Molecular weight|| |
Smad1 (phospho Ser465) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Smad1 (phospho Ser465) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Mothers against decapentaplegic homolog 1 antibody, MAD homolog 1 antibody, Mothers against DPP homolog 1 antibody, JV4-1 antibody, Mad-related protein 1 antibody, SMAD family member 1 antibody, SMAD 1 antibody, Smad1 antibody, hSMAD1 antibody, Transforming growth factor-beta-signaling protein 1 antibody, BSP-1 antibody
|Protein names|| |
Mothers against decapentaplegic homolog 1 , MAD homolog 1 , Mothers against DPP homolog 1 , JV4-1 , Mad-related protein 1 , SMAD family member 1 , SMAD 1 , Smad1 , hSMAD1 , Transforming growth factor-beta-signaling protein 1 , BSP-1
|Protein function|| |
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
|Protein tissue specificity|| |
Ubiquitous. Highest expression seen in the heart and skeletal muscle.
|Involvement in disease|| |
Note: SMAD1 variants may be associated with susceptibility to pulmonary hypertension, a disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs. .
|Protein sequence and domain|| |
The MH2 domain mediates phosphorylation-dependent trimerization through L3 loop binding of phosphoserines in the adjacent subunit. / Belongs to the dwarfin/SMAD family. / Contains 1 MH1 (MAD homology 1) domain. / Contains 1 MH2 (MAD homology 2) domain.
|Protein post-translational modifications|| |
Phosphorylation of the C-terminal SVS motif by BMP type 1 receptor kinase activates SMAD1 by promoting dissociation from the receptor and trimerization with SMAD4. / Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading to its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes.
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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