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Rabbit Polyclonal Phospho-SNAI 1 (S246) antibody (STJ90728)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for SNAI 1 (phospho Ser246) Polyclonal Antibody.
Check alternative names for the antibodyExpand
SNAI1 antibody, SNAH antibody,|dJ710H13.1 antibody|Protein sna antibody|Protein snail homolog 1 antibody|Protein snail homolog antibody|SLUGH2 antibody|SNA antibody|Sna protein antibody|SNAH antibody|SNAI antibody|snai1 antibody|SNAI1_HUMAN antibody|Snail 1 homolog antibody|Snail 1 zinc finger protein antibody|SNAIL antibody|Snail homolog 1 (Drosophila) antibody|SNAIL, Drosophila, homolog of, 1 antibody|SNAIL1 antibody|Zinc finger protein SNAI1 antibody|Anti-SNAIL + SLUG antibody (ab180714)
SCBT cat No: To be updated
SNAI 1 (phospho Ser246) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Monkey
Phospho-SNAI 1 (S246) Polyclonal Antibody detects endogenous levels of SNAI 1 protein only when phosphorylated at S246.
Synthesized phospho-peptide derived from SNAI 1 (phospho Ser246) at AA range 190-270
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;
|Molecular weight|| |
SNAI 1 (phospho Ser246) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
SNAI 1 (phospho Ser246) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Zinc finger protein SNAI1 antibody, Protein snail homolog 1 antibody, Protein sna antibody
|Protein names|| |
Zinc finger protein SNAI1 , Protein snail homolog 1 , Protein sna
|Protein function|| |
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5′-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
|Protein tissue specificity|| |
Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.
|Protein sequence and domain|| |
Belongs to the snail C2H2-type zinc-finger protein family. / Contains 4 C2H2-type zinc fingers.
|Protein post-translational modifications|| |
Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for BTRC ubiquitination. Phosphorylation by CSNK1E, probably at Ser-104, provides the priming site for the subsequent phosphorylation by GSK3B, probably at Ser-100 and Ser-96. Phosphorylation by PAK1 may modulate its transcriptional activity by promoting increased accumulation in the nucleus. Phosphorylation at Ser-11 and Ser-92 positively regulates its functions in induction of EMT and cell survival, respectively. Phosphorylation by LATS2, upon mitotic stress, oncogenic stress or Hippo pathway activation, occurs in the nucleus and promotes nuclear retention and stabilization of total cellular protein level. / Ubiquitinated on Lys-98, Lys-137 and Lys-146 by FBXL14 and BTRC leading to degradation. BTRC-triggered ubiquitination requires previous GSK3B-mediated SNAI1 phosphorylation. Ubiquitination induced upon interaction with NOTCH1 or TP53/p53 is mediated by MDM2. / O-GlcNAcylation at Ser-112 is enhanced in hyperglycaemic conditions, it opposes phosphorylation by GSK3B, and stabilizes the protein. / ADP-ribosylation by PARP1 increases protein half-life and may be involved in TGFB-induced SNAI1 up-regulation.
|Protein cellular localization|| |
Nucleus / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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