Rabbit Polyclonal Phospho-SNCA-Y125 antibody (AP0241)

$99.00$259.00

Reactivity: Human
Applications: WB,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-SNCA-Y125 antibody (AP0241)

Supplier: ABclonal Inc.

Recommended applications: WB,IF

Recommended dilution:

WB 1:500 – 1:2000
IF 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PD1 antibody; NACP antibody; PARK1 antibody; PARK4 antibody;
Alpha synuclein antibody|Beta synuclein antibody|NACP antibody|Non A beta component of AD amyloid antibody|PARK1 antibody|PARK4 antibody|PD1 antibody|SNCA antibody|SNCB antibody|Synuclein alpha antibody|Synuclein beta antibody|Anti-alpha Synuclein antibody [MJFR1] (ab138501)

SCBT cat No: sc-10717|sc-376010|sc-67321|sc-54758|sc-136385|sc-271066|sc-13991|sc-48349|sc-69699|sc-514908|sc-7012|sc-32281|sc-100291|sc-1477|sc-31358|sc-28982|sc-1476|sc-26416|sc-27136|sc-365559|sc-390884|sc-27099|sc-10721|sc-1475|

Name

Rabbit Polyclonal Phospho-SNCA-Y125 antibody

Catalogue No.

AP0241

Reactivity

Human

Immunogen

A phospho specific peptide corresponding to residues surrounding Y125 of human SNCA

Host

Rabbit

Applications

WB, IF

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

18kDa

Formulation

Phospho-SNCA-Y125 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PD1 antibody; NACP antibody; PARK1 antibody; PARK4 antibody;

Protein names

PD1; NACP; PARK1; PARK4;

Protein function

May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

Protein tissue specificity

Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.

Protein sequence and domain

Belongs to the synuclein family. The 'non A-beta component of Alzheimer disease amyloid plaque' domain (NAC domain) is involved in fibrils formation. The middle hydrophobic region forms the core of the filaments. The C-terminus may regulate aggregation and determine the diameter of the filaments.

Protein post-translational modifications

Phosphorylated, predominantly on serine residues. Phosphorylation by CK1 appears to occur on residues distinct from the residue phosphorylated by other kinases. Phosphorylation of Ser-129 is selective and extensive in synucleinopathy lesions. In vitro, phosphorylation at Ser-129 promoted insoluble fibril formation. Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress.; Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers.; Ubiquitinated. The predominant conjugate is the diubiquitinated form (By similarity).; Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.

Protein cellular localization

Cytoplasm, cytosol . Membrane . Nucleus . Cell junction, synapse . Secreted . Note=Membrane-bound in dopaminergic neurons.

Background

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Neurobiology/">Neurobiology</a>><a href="http://antibodyplus.com/product-tag/synuclein/">synuclein</a><br><a href="http://antibodyplus.com/product-tag/Neurobiology/"&gt; (View all antibody categories related to Neurobiology)</a>

Note

AntibodyPlus can customize Phospho-SNCA-Y125 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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