Rabbit Polyclonal Phospho-SREBP-1 (S439) antibody (STJ90993)

$99.00$319.00

Reactivity: Human, Rat
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-SREBP-1 (S439) antibody (STJ90993)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for SREBP-1 (phospho Ser439) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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SREBF1 antibody, BHLHD1 antibody, SREBP1 antibody,|ADD 1 antibody|bHLHd1 antibody|Class D basic helix-loop-helix protein 1 antibody|D630008H06 antibody|Processed sterol regulatory element-binding protein 1 antibody|SRBP1_HUMAN antibody|SREBF 1 antibody|SREBF1 antibody|SREBP 1 antibody|SREBP 1c antibody|SREBP-1 antibody|SREBP1 antibody|Sterol regulatory element binding protein 1 antibody|Sterol Regulatory Element Binding Transcription Factor 1 / Protein 1 antibody|Sterol regulatory element binding transcription factor 1 antibody|Sterol regulatory element-binding transcription factor 1 antibody|Anti-SREBP1 antibody (ab28481)
SCBT cat No: To be updated

 

Name

SREBP-1 (phospho Ser439) Polyclonal Antibody

Catalogue No.

STJ90993

Reactivity

Human, Rat

Specificity

Phospho-SREBP-1 (S439) Polyclonal Antibody detects endogenous levels of SREBP-1 protein only when phosphorylated at S439.

Immunogen

Synthesized phospho-peptide derived from SREBP-1 (phospho Ser439) at AA range 380-460

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

122 kDa

Formulation

SREBP-1 (phospho Ser439) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

SREBP-1 (phospho Ser439) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Sterol regulatory element-binding protein 1 antibody, SREBP-1 antibody, Class D basic helix-loop-helix protein 1 antibody, bHLHd1 antibody, Sterol regulatory element-binding transcription factor 1 antibody

Database links

Human UniProt/Swiss-Prot:P36956;Mouse UniPort/Swiss-Prot: Q9WTN3;Rat UniProt/Swiss-Port: P56720;Human Entrez Gene: 6720;Mouse Entrez Gene: 20787;Rat Entrez Gene: Rn.198857

Protein names

Sterol regulatory element-binding protein 1 , SREBP-1 , Class D basic helix-loop-helix protein 1 , bHLHd1 , Sterol regulatory element-binding transcription factor 1

Protein function

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5′-ATCACCCCAC-3′). Has dual sequence specificity binding to both an E-box motif (5′-ATCACGTGA-3′) and to SRE-1 (5′-ATCACCCCAC-3′).

Protein tissue specificity

Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.

Protein sequence and domain

Belongs to the SREBP family. / Contains 1 bHLH (basic helix-loop-helix) domain.

Protein post-translational modifications

At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7. / Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression. Phosphorylation at Ser-402 by SIK1 represses activity possibly by inhibiting DNA-binding (By similarity).

Protein cellular localization

Endoplasmic reticulum membrane / Multi-pass membrane protein / Golgi apparatus membrane / Multi-pass membrane protein / Cytoplasmic vesicle > COPII-coated vesicle membrane / Multi-pass membrane protein / Nucleus / Nucleus / Nucleus

Research area

All research areas>Transcription Regulators>SREBP
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize SREBP-1 (phospho Ser439) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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