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Rabbit Polyclonal Phospho-STAM2 (Y192) antibody (STJ90559)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for STAM2 (phospho Tyr192) Polyclonal Antibody.
Check alternative names for the antibodyExpand
STAM2 antibody, HBP antibody,|DKFZp564C047 antibody|Hbp antibody|Hrs-binding protein antibody|HSE1 homolog antibody|Signal transducing adapter molecule 2 antibody|Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 antibody|Signal transducing adaptor molecule 2A antibody|Signal transducing adaptor molecule 2B antibody|Signal transducing adaptor molecule antibody|STAM like protein containing SH3 and ITAM domains 2 antibody|STAM-2 antibody|Stam2 antibody|STAM2_HUMAN antibody|STAM2A antibody|STAM2B antibody|Anti-STAM2 antibody [EPR8688] (ab151545)
SCBT cat No: To be updated
STAM2 (phospho Tyr192) Polyclonal Antibody
|Catalogue No.|| |
Phospho-STAM2 (Y192) Polyclonal Antibody detects endogenous levels of STAM2 protein only when phosphorylated at Y192.
Synthesized phospho-peptide derived from STAM2 (phospho Tyr192) at AA range 130-210
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
STAM2 (phospho Tyr192) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
STAM2 (phospho Tyr192) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Signal transducing adapter molecule 2 antibody, STAM-2 antibody, Hrs-binding protein antibody
|Protein names|| |
Signal transducing adapter molecule 2 , STAM-2 , Hrs-binding protein
|Protein function|| |
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
|Protein tissue specificity|| |
|Protein sequence and domain|| |
The VHS and UIM domains mediate the interaction with ubiquitinated proteins. / The SH3 domain mediates the interaction with USP8. / Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain. / Belongs to the STAM family. / Contains 1 ITAM domain. / Contains 1 SH3 domain. / Contains 1 UIM (ubiquitin-interacting motif) domain. / Contains 1 VHS domain.
|Protein post-translational modifications|| |
Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.
|Protein cellular localization|| |
Cytoplasm / Early endosome membrane / Peripheral membrane protein / Cytoplasmic side
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St John’s Laboratory Ltd.
|Product type|| |
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