Rabbit Polyclonal Phospho-Stat2 (Y690) antibody (STJ90772)

$99.00$319.00

Reactivity: Human, Rat
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Stat2 (Y690) antibody (STJ90772)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Stat2 (phospho Tyr690) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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STAT2 antibody,|Homo sapiens interferon alpha induced transcriptional activator antibody|interferon alpha induced transcriptional activator antibody|ISGF 3 antibody|ISGF3 antibody|MGC59816 antibody|P113 antibody|signal transducer and activator of transcription 2 113kD antibody|Signal transducer and activator of transcription 2 antibody|STAT113 antibody|Stat2 antibody|STAT2_HUMAN antibody|Phospho anti-STAT2 (Y690) antibody (ab53132)
SCBT cat No: sc-21689|sc-56747|sc-71792|sc-81523|sc-8059|sc-293059|sc-136193|sc-135649|sc-21876|

 

Name

Stat2 (phospho Tyr690) Polyclonal Antibody

Catalogue No.

STJ90772

Reactivity

Human, Rat

Specificity

Phospho-Stat2 (Y690) Polyclonal Antibody detects endogenous levels of Stat2 protein only when phosphorylated at Y690.

Immunogen

Synthesized phospho-peptide derived from Stat2 (phospho Tyr690) at AA range 630-710

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

113 kDa

Formulation

Stat2 (phospho Tyr690) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Stat2 (phospho Tyr690) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Signal transducer and activator of transcription 2 antibody, p113 antibody

Database links

Human UniProt/Swiss-Prot:P52630;Rat UniProt/Swiss-Port: Q5XI26;Human Entrez Gene: 6773;Mouse Entrez Gene: 20847;Rat Entrez Gene: Rn.24237

Protein names

Signal transducer and activator of transcription 2 , p113

Protein function

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Involvement in disease

Immunodeficiency 44 (IMD44) [MIM:616636]: An autosomal recessive disorder characterized by increased susceptibility to viral infection, resulting in some patients in encephalopathy and infection-associated neurologic decompensation. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the transcription factor STAT family. / Contains 1 SH2 domain.

Protein post-translational modifications

Tyrosine phosphorylated in response to IFN-alpha. Phosphorylation at Ser-287 negatively regulates the transcriptional response.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Transcription Regulators>Stat
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Stat2 (phospho Tyr690) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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