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Rabbit Polyclonal Phospho-Stat2 (Y690) antibody (STJ90772)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Stat2 (phospho Tyr690) Polyclonal Antibody.
Check alternative names for the antibodyExpand
STAT2 antibody,|Homo sapiens interferon alpha induced transcriptional activator antibody|interferon alpha induced transcriptional activator antibody|ISGF 3 antibody|ISGF3 antibody|MGC59816 antibody|P113 antibody|signal transducer and activator of transcription 2 113kD antibody|Signal transducer and activator of transcription 2 antibody|STAT113 antibody|Stat2 antibody|STAT2_HUMAN antibody|Phospho anti-STAT2 (Y690) antibody (ab53132)
SCBT cat No: sc-21689|sc-56747|sc-71792|sc-81523|sc-8059|sc-293059|sc-136193|sc-135649|sc-21876|
Stat2 (phospho Tyr690) Polyclonal Antibody
|Catalogue No.|| |
Phospho-Stat2 (Y690) Polyclonal Antibody detects endogenous levels of Stat2 protein only when phosphorylated at Y690.
Synthesized phospho-peptide derived from Stat2 (phospho Tyr690) at AA range 630-710
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
|Molecular weight|| |
Stat2 (phospho Tyr690) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Stat2 (phospho Tyr690) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Signal transducer and activator of transcription 2 antibody, p113 antibody
|Protein names|| |
Signal transducer and activator of transcription 2 , p113
|Protein function|| |
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
|Involvement in disease|| |
Immunodeficiency 44 (IMD44) [MIM:616636]: An autosomal recessive disorder characterized by increased susceptibility to viral infection, resulting in some patients in encephalopathy and infection-associated neurologic decompensation. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the transcription factor STAT family. / Contains 1 SH2 domain.
|Protein post-translational modifications|| |
Tyrosine phosphorylated in response to IFN-alpha. Phosphorylation at Ser-287 negatively regulates the transcriptional response.
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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