Rabbit Polyclonal Phospho-STMN1-S25 antibody (AP0220)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-STMN1-S25 antibody (AP0220)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

Lag antibody; SMN antibody; OP18 antibody; PP17 antibody; PP19 antibody; PR22 antibody; LAP18 antibody; C1orf215 antibody;
C1orf215 antibody|Lag antibody|LAP 18 antibody|LAP18 antibody|Leukemia associated phosphoprotein p18 antibody|Leukemia-associated phosphoprotein p18 antibody|Metablastin antibody|Oncoprotein 18 antibody|OP 18 antibody|Op18 antibody|p18 antibody|p19 antibody|Phosphoprotein 19 antibody|Phosphoprotein p19 antibody|pp17 antibody|pp19 antibody|PR22 antibody|Pr22 protein antibody|Prosolin antibody|Protein Pr22 antibody|SMN antibody|Stathmin antibody|Stathmin1 antibody|STMN 1 antibody|Stmn1 antibody|STMN1_HUMAN antibody|Anti-Stathmin 1 antibody [EP1573Y] (ab52630)

SCBT cat No: sc-130333|sc-136010|sc-48362|sc-55531|sc-20796|sc-10899|sc-30573|sc-367890|sc-30572|sc-82004|

Name

Rabbit Polyclonal Phospho-STMN1-S25 antibody

Catalogue No.

AP0220

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding S25 of human STMN1

Host

Rabbit

Applications

WB, IHC

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

19kDa

Formulation

Phospho-STMN1-S25 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

Lag antibody; SMN antibody; OP18 antibody; PP17 antibody; PP19 antibody; PR22 antibody; LAP18 antibody; C1orf215 antibody;

Protein names

Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215;

Protein function

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).

Protein tissue specificity

Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.

Protein sequence and domain

Belongs to the stathmin family.; Contains 1 SLD (stathmin-like) domain.

Protein post-translational modifications

Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.

Protein cellular localization

Cytoplasm, cytoskeleton.

Background

This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Signaling-Intermediates/">Signaling Intermediates</a>><a href="http://antibodyplus.com/product-tag/Op18/">Op18</a><br><a href="http://antibodyplus.com/product-tag/Signaling-Intermediates/"&gt; (View all antibody categories related to Signaling Intermediates)</a>

Note

AntibodyPlus can customize Phospho-STMN1-S25 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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