Rabbit Polyclonal Phospho-SUFU-S342 antibody (AP0457)

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Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-SUFU-S342 antibody (AP0457)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal Phospho-SUFU-S342 antibody.

Alternative names:

Check alternative names for the antibody

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SUFUH antibody; SUFUXL antibody; PRO1280 antibody;
OTTHUMP00000020374 antibody|OTTHUMP00000020377 antibody|OTTHUMP00000020379 antibody|PRO1280 antibody|SU FU antibody|SU(F)U antibody|Su(fu) antibody|SUFU antibody|SUFU negative regulator of hedgehog signaling antibody|SUFU_HUMAN antibody|SUFUH antibody|SUFUXL antibody|Suppressor of fused homolog (Drosophila) antibody|Suppressor of fused homolog antibody|Anti-Suppressor of Fused antibody (ab28083)

SCBT cat No:

Name

Rabbit Polyclonal Phospho-SUFU-S342 antibody

Catalogue No.

AP0457

Reactivity

Human

Immunogen

A phospho specific peptide corresponding to residues surrounding S342 of human SUFU

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

54kDa

Formulation

Phospho-SUFU-S342 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

SUFUH antibody; SUFUXL antibody; PRO1280 antibody;

Protein names

SUFUH; SUFUXL; PRO1280;

Protein function

Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes (PubMed:15367681, PubMed:24311597, PubMed:24217340). Down-regulates GLI2-mediated transactivation of target genes (PubMed:24311597, PubMed:24217340). Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10806483, PubMed:24217340). Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for normal embryonic development. Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity).

Protein tissue specificity

Ubiquitous in adult tissues. Detected in osteoblasts of the perichondrium in the developing limb of 12-week old embryos. Isoform 1 is detected in fetal brain, lung, kidney and testis. Isoform 2 is detected in fetal testis, and at much lower levels in fetal brain, lung and kidney.

Protein sequence and domain

Belongs to the SUFU family.

Protein cellular localization

Cytoplasm . Nucleus .

Background

The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.

Note

AntibodyPlus can customize Phospho-SUFU-S342 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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