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Rabbit Polyclonal Phospho-Tak1 (S439) antibody (STJ90947)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for Tak1 (phospho Ser439) Polyclonal Antibody.
Check alternative names for the antibodyExpand
MAP3K7 antibody, TAK1 antibody,|M3K7_HUMAN antibody|MAP3K 7 antibody|Map3k7 antibody|MEKK7 antibody|Mitogen activated protein kinase kinase kinase 7 antibody|Mitogen-activated protein kinase kinase kinase 7 antibody|TAK1 antibody|TGF beta activated kinase 1 antibody|TGF-beta-activated kinase 1 antibody|TGF1a antibody|Transforming growth factor beta activated kinase 1 antibody|Transforming growth factor-beta-activated kinase 1 antibody|Anti-TAK1 antibody [EPR5984] (ab109526)
SCBT cat No: sc-130219|sc-248320|sc-71794|sc-32275|sc-32276|
Tak1 (phospho Ser439) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Tak1 (S439) Polyclonal Antibody detects endogenous levels of Tak1 protein only when phosphorylated at S439.
Synthesized phospho-peptide derived from Tak1 (phospho Ser439) at AA range 380-460
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
Tak1 (phospho Ser439) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tak1 (phospho Ser439) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Mitogen-activated protein kinase kinase kinase 7 antibody, Transforming growth factor-beta-activated kinase 1 antibody, TGF-beta-activated kinase 1 antibody
|Protein names|| |
Mitogen-activated protein kinase kinase kinase 7 , Transforming growth factor-beta-activated kinase 1 , TGF-beta-activated kinase 1
|Protein function|| |
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity. / ATP + a protein = ADP + a phosphoprotein. / Mg2+ / Activated by proinflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by ‘Lys-63’-linked polyubiquitination and by autophosphorylation. Association with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2 promotes activation through autophosphorylation, whereas PPM1B/PP2CB, PP2A and PPP6C dephosphorylation leads to inactivation.
|Protein tissue specificity|| |
Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Association with TAB1/MAP3K7IP1 promotes autophosphorylation at Ser-192 and subsequent activation. Association with TAB2/MAP3K7IP2, itself associated with free unanchored Lys-63 polyubiquitin chain, promotes autophosphorylation and subsequent activation of MAP3K7. Dephosphorylation at Ser-192 by PPM1B/PP2CB and at Thr-187 by PP2A and PPP6C leads to inactivation. / ‘Lys-48’-linked polyubiquitination at Lys-72 is induced by TNFalpha, and leads to proteasomal degradation. Requires ‘Lys-63’-linked polyubiquitination for autophosphorylation and subsequent activation. ‘Lys-63’-linked ubiquitination does not lead to proteasomal degradation. Deubiquitinated by CYLD, a protease that selectively cleaves ‘Lys-63’-linked ubiquitin chains. Deubiquitinated by Y.enterocolitica YopP.
|Protein cellular localization|| |
Cytoplasm / Cell membrane / Peripheral membrane protein / Cytoplasmic side
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St John’s Laboratory Ltd.
|Product type|| |
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