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Rabbit Polyclonal Phospho-TFII-I (Y248) antibody (STJ90480)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for TFII-I (phospho Tyr248) Polyclonal Antibody.
Check alternative names for the antibodyExpand
GTF2I antibody, BAP135 antibody, WBSCR6 antibody,|BAP 135 antibody|BAP-135 antibody|BAP135 antibody|Bruton tyrosine kinase associated protein 135 antibody|Bruton tyrosine kinase-associated protein 135 antibody|BTK associated protein 135 antibody|BTK associated protein 135kD antibody|BTK associated protein antibody|BTK-associated protein 135 antibody|BTKAP 1 antibody|BTKAP1 antibody|DIWS antibody|FLJ38776 antibody|FLJ56355 antibody|General transcription factor II i antibody|General transcription factor II-I antibody|General transcription factor IIi antibody|GTF 2I antibody|Gtf2i antibody|GTF2I_HUMAN antibody|GTFII I antibody|GTFII-I antibody|IB 291 antibody|IB291 antibody|SPIN antibody|SRF Phox 1 interacting protein antibody|SRF Phox1 interacting protein antibody|SRF-Phox1-interacting protein antibody|TFII-I antibody|Transcription factor II I antibody|WBS antibody|WBSCR 6 antibody|WBSCR6 antibody|Williams Beuren syndrome chromosome region 6 antibody|Williams Beuren syndrome chromosome region 6 protein antibody|Williams-Beuren syndrome chromosomal region 6 protein antibody|Anti-TFII I antibody [EPR7696] (ab134133)
SCBT cat No: To be updated
TFII-I (phospho Tyr248) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-TFII-I (Y248) Polyclonal Antibody detects endogenous levels of TFII-I protein only when phosphorylated at Y248.
Synthesized phospho-peptide derived from TFII-I (phospho Tyr248) at AA range 190-270
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:5000;
|Molecular weight|| |
TFII-I (phospho Tyr248) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
TFII-I (phospho Tyr248) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
General transcription factor II-I antibody, GTFII-I antibody, TFII-I antibody, Bruton tyrosine kinase-associated protein 135 antibody, BAP-135 antibody, BTK-associated protein 135 antibody, SRF-Phox1-interacting protein antibody, SPIN antibody, Williams-Beuren syndrome chromosomal region 6 protein antibody
|Protein names|| |
General transcription factor II-I , GTFII-I , TFII-I , Bruton tyrosine kinase-associated protein 135 , BAP-135 , BTK-associated protein 135 , SRF-Phox1-interacting protein , SPIN , Williams-Beuren syndrome chromosomal region 6 protein
|Protein function|| |
Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.
|Protein tissue specificity|| |
Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues.
|Involvement in disease|| |
Note: GTF2I is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of GTF2I may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
|Protein sequence and domain|| |
Belongs to the TFII-I family. / Contains 6 GTF2I-like repeats.
|Protein post-translational modifications|| |
Transiently phosphorylated on tyrosine residues by BTK in response to B-cell receptor stimulation. Phosphorylation on Tyr-248 and Tyr-398, and perhaps, on Tyr-503 contributes to BTK-mediated transcriptional activation. / Sumoylated.
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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