Rabbit Polyclonal Phospho-TFII-I (Y248) antibody (STJ90480)

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Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-TFII-I (Y248) antibody (STJ90480)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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GTF2I antibody, BAP135 antibody, WBSCR6 antibody,|BAP 135 antibody|BAP-135 antibody|BAP135 antibody|Bruton tyrosine kinase associated protein 135 antibody|Bruton tyrosine kinase-associated protein 135 antibody|BTK associated protein 135 antibody|BTK associated protein 135kD antibody|BTK associated protein antibody|BTK-associated protein 135 antibody|BTKAP 1 antibody|BTKAP1 antibody|DIWS antibody|FLJ38776 antibody|FLJ56355 antibody|General transcription factor II i antibody|General transcription factor II-I antibody|General transcription factor IIi antibody|GTF 2I antibody|Gtf2i antibody|GTF2I_HUMAN antibody|GTFII I antibody|GTFII-I antibody|IB 291 antibody|IB291 antibody|SPIN antibody|SRF Phox 1 interacting protein antibody|SRF Phox1 interacting protein antibody|SRF-Phox1-interacting protein antibody|TFII-I antibody|Transcription factor II I antibody|WBS antibody|WBSCR 6 antibody|WBSCR6 antibody|Williams Beuren syndrome chromosome region 6 antibody|Williams Beuren syndrome chromosome region 6 protein antibody|Williams-Beuren syndrome chromosomal region 6 protein antibody|Anti-TFII I antibody [EPR7696] (ab134133)
SCBT cat No: To be updated

 

Name

TFII-I (phospho Tyr248) Polyclonal Antibody

Catalogue No.

STJ90480

Reactivity

Human, Mouse, Rat

Specificity

Phospho-TFII-I (Y248) Polyclonal Antibody detects endogenous levels of TFII-I protein only when phosphorylated at Y248.

Immunogen

Synthesized phospho-peptide derived from TFII-I (phospho Tyr248) at AA range 190-270

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

115 kDa

Formulation

TFII-I (phospho Tyr248) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

TFII-I (phospho Tyr248) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

General transcription factor II-I antibody, GTFII-I antibody, TFII-I antibody, Bruton tyrosine kinase-associated protein 135 antibody, BAP-135 antibody, BTK-associated protein 135 antibody, SRF-Phox1-interacting protein antibody, SPIN antibody, Williams-Beuren syndrome chromosomal region 6 protein antibody

Database links

Human UniProt/Swiss-Prot:P78347;Mouse UniPort/Swiss-Prot: Q9ESZ8;Rat UniProt/Swiss-Port: Q5U2Y1;Human Entrez Gene: 2969;Mouse Entrez Gene: 14886;Rat Entrez Gene: Rn.27575

Protein names

General transcription factor II-I , GTFII-I , TFII-I , Bruton tyrosine kinase-associated protein 135 , BAP-135 , BTK-associated protein 135 , SRF-Phox1-interacting protein , SPIN , Williams-Beuren syndrome chromosomal region 6 protein

Protein function

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.

Protein tissue specificity

Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues.

Involvement in disease

Note: GTF2I is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of GTF2I may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

Protein sequence and domain

Belongs to the TFII-I family. / Contains 6 GTF2I-like repeats.

Protein post-translational modifications

Transiently phosphorylated on tyrosine residues by BTK in response to B-cell receptor stimulation. Phosphorylation on Tyr-248 and Tyr-398, and perhaps, on Tyr-503 contributes to BTK-mediated transcriptional activation. / Sumoylated.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Transcription Regulators>TFII
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize TFII-I (phospho Tyr248) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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