Rabbit Polyclonal Phospho-TIP60 (S86) antibody (STJ90502)

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Reactivity: Human, Mouse
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-TIP60 (S86) antibody (STJ90502)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:40000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for TIP60 (phospho Ser86) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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KAT5 antibody, HTATIP antibody, TIP60 antibody,|60 kDa Tat interactive protein antibody|60 kDa Tat-interactive protein antibody|cPLA(2) interacting protein antibody|cPLA(2)-interacting protein antibody|cPLA2 antibody|cPLA2 interacting protein antibody|ESA1 antibody|Histone acetyltransferase HTATIP antibody|Histone acetyltransferase KAT5 antibody|HIV 1 Tat interactive protein antibody|HIV 1 Tat interactive protein, 60kDa antibody|HIV-1 Tat interactive protein antibody|HTATIP antibody|HTATIP1 antibody|K(lysine) acetyltransferase 5 antibody|K-acetyltransferase 5 antibody|KAT5 antibody|KAT5_HUMAN antibody|Lysine acetyltransferase 5 antibody|PLIP antibody|Tat interacting protein, 60kDa antibody|TIP antibody|Tip60 antibody|Anti-KAT5 / Tip60 antibody (ab23886)
SCBT cat No: To be updated

 

Name

TIP60 (phospho Ser86) Polyclonal Antibody

Catalogue No.

STJ90502

Reactivity

Human, Mouse

Specificity

Phospho-TIP60 (S86) Polyclonal Antibody detects endogenous levels of TIP60 protein only when phosphorylated at S86.

Immunogen

Synthesized phospho-peptide derived from TIP60 (phospho Ser86) at AA range 30-110

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:40000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

65 kDa

Formulation

TIP60 (phospho Ser86) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

TIP60 (phospho Ser86) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Histone acetyltransferase KAT5 antibody, 60 kDa Tat-interactive protein antibody, Tip60 antibody, Histone acetyltransferase HTATIP antibody, HIV-1 Tat interactive protein antibody, Lysine acetyltransferase 5 antibody, cPLAantibody, 2 antibody,-interacting protein antibody

Database links

Human UniProt/Swiss-Prot:Q92993;Mouse UniPort/Swiss-Prot: Q8CHK4;Rat UniProt/Swiss-Port: Q99MK2;Human Entrez Gene: 10524;Mouse Entrez Gene: 81601;Rat Entrez Gene: Rn.6629

Protein names

Histone acetyltransferase KAT5 , 60 kDa Tat-interactive protein , Tip60 , Histone acetyltransferase HTATIP , HIV-1 Tat interactive protein , Lysine acetyltransferase 5 , cPLA, 2 ,-interacting protein

Protein function

Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity . / Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Protein sequence and domain

Belongs to the MYST (SAS/MOZ) family. / Contains 1 C2HC-type zinc finger. / Contains 1 MYST-type HAT (histone acetyltransferase) domain.

Protein post-translational modifications

Sumoylated by UBE2I at Lys-430 and Lys-451, leading to increase of its histone acetyltransferase activity in UV-induced DNA damage response, as well as its translocation to nuclear bodies. / Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M phase. The phosphorylated form has a higher HAT activity. / Ubiquitinated by MDM2, leading to its proteasome-dependent degradation. / Autoacetylation at Lys-327 is required for proper function.

Protein cellular localization

Nucleus / Nucleus > nucleolus / Cytoplasm > perinuclear region

Research area

All research areas>Transcription Regulators>TIP60
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize TIP60 (phospho Ser86) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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