Rabbit Polyclonal Phospho-Topo IIalpha (S1106) antibody (STJ90919)

$99.00$319.00

Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Topo IIalpha (S1106) antibody (STJ90919)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Topo IIalpha (phospho Ser1106) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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TOP2A antibody, TOP2 antibody,|alpha isozyme antibody|ATP hydrolyzing DNA topoisomerase II alfa antibody|DNA gyrase antibody|DNA topoisomerase (ATP hydrolyzing) antibody|DNA topoisomerase 2 alpha antibody|DNA topoisomerase 2-alpha antibody|DNA topoisomerase II 170 kD antibody|DNA topoisomerase II alpha isozyme antibody|DNA topoisomerase II antibody|DNA Topoisomerase2 antibody|TOP 2A antibody|TOP2 antibody|TOP2A antibody|TOP2A_HUMAN antibody|Topoisomerase DNA II alpha 170kDa antibody|TP2A antibody|Anti-Topoisomerase II alpha antibody [EP1102Y] (ab52934)
SCBT cat No: sc-16742|sc-240796|sc-130570|sc-390101|sc-135672|sc-292265|sc-393922|sc-30339|sc-30337|sc-130858|sc-1114|sc-28905|sc-10867|

 

Name

Topo IIalpha (phospho Ser1106) Polyclonal Antibody

Catalogue No.

STJ90919

Reactivity

Human

Specificity

Phospho-Topo IIalpha (S1106) Polyclonal Antibody detects endogenous levels of Topo IIalpha protein only when phosphorylated at S1106.

Immunogen

Synthesized phospho-peptide derived from Topo IIalpha (phospho Ser1106) at AA range 1050-1130

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

174 kDa

Formulation

Topo IIalpha (phospho Ser1106) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Topo IIalpha (phospho Ser1106) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

DNA topoisomerase 2-alpha antibody, DNA topoisomerase II, alpha isozyme antibody

Database links

Human UniProt/Swiss-Prot:P11388;Mouse UniPort/Swiss-Prot: Q01320;Rat UniProt/Swiss-Port: P41516;Human Entrez Gene: 7153;Mouse Entrez Gene: 21973;Rat Entrez Gene: Rn.90996

Protein names

DNA topoisomerase 2-alpha , DNA topoisomerase II, alpha isozyme

Protein function

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity). / ATP-dependent breakage, passage and rejoining of double-stranded DNA. / Mg2+ / Specifically inhibited by the intercalating agent amsacrine.

Protein sequence and domain

The N-terminus has several structural domains; the ATPase domain (about residues 1-265), the transducer domain (about 266-428) and the toprim domain (455-572) (PubMed:25202966). Comparing different structures shows ATP hydrolysis induces domain shifts in the N-terminus that are probably part of the mechanism of DNA cleavage and rejoining (PubMed:25202966). / Belongs to the type II topoisomerase family. / Contains 1 Toprim domain.

Protein post-translational modifications

Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.

Protein cellular localization

Cytoplasm / Nucleus > nucleoplasm

Research area

All research areas>Transcription Regulators>Topo II alpha
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Topo IIalpha (phospho Ser1106) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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