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Rabbit Polyclonal Phospho-Topo IIalpha (S1106) antibody (STJ90919)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for Topo IIalpha (phospho Ser1106) Polyclonal Antibody.
Check alternative names for the antibodyExpand
TOP2A antibody, TOP2 antibody,|alpha isozyme antibody|ATP hydrolyzing DNA topoisomerase II alfa antibody|DNA gyrase antibody|DNA topoisomerase (ATP hydrolyzing) antibody|DNA topoisomerase 2 alpha antibody|DNA topoisomerase 2-alpha antibody|DNA topoisomerase II 170 kD antibody|DNA topoisomerase II alpha isozyme antibody|DNA topoisomerase II antibody|DNA Topoisomerase2 antibody|TOP 2A antibody|TOP2 antibody|TOP2A antibody|TOP2A_HUMAN antibody|Topoisomerase DNA II alpha 170kDa antibody|TP2A antibody|Anti-Topoisomerase II alpha antibody [EP1102Y] (ab52934)
SCBT cat No: sc-16742|sc-240796|sc-130570|sc-390101|sc-135672|sc-292265|sc-393922|sc-30339|sc-30337|sc-130858|sc-1114|sc-28905|sc-10867|
Topo IIalpha (phospho Ser1106) Polyclonal Antibody
|Catalogue No.|| |
Phospho-Topo IIalpha (S1106) Polyclonal Antibody detects endogenous levels of Topo IIalpha protein only when phosphorylated at S1106.
Synthesized phospho-peptide derived from Topo IIalpha (phospho Ser1106) at AA range 1050-1130
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
Topo IIalpha (phospho Ser1106) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Topo IIalpha (phospho Ser1106) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
DNA topoisomerase 2-alpha antibody, DNA topoisomerase II, alpha isozyme antibody
|Protein names|| |
DNA topoisomerase 2-alpha , DNA topoisomerase II, alpha isozyme
|Protein function|| |
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity). / ATP-dependent breakage, passage and rejoining of double-stranded DNA. / Mg2+ / Specifically inhibited by the intercalating agent amsacrine.
|Protein sequence and domain|| |
The N-terminus has several structural domains; the ATPase domain (about residues 1-265), the transducer domain (about 266-428) and the toprim domain (455-572) (PubMed:25202966). Comparing different structures shows ATP hydrolysis induces domain shifts in the N-terminus that are probably part of the mechanism of DNA cleavage and rejoining (PubMed:25202966). / Belongs to the type II topoisomerase family. / Contains 1 Toprim domain.
|Protein post-translational modifications|| |
Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.
|Protein cellular localization|| |
Cytoplasm / Nucleus > nucleoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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