Rabbit Polyclonal Phospho-Topo IIalpha (T1343) antibody (STJ90606)


Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Topo IIalpha (T1343) antibody (STJ90606)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Topo IIalpha (phospho Thr1343) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody


TOP2A antibody, TOP2 antibody,|alpha isozyme antibody|ATP hydrolyzing DNA topoisomerase II alfa antibody|DNA gyrase antibody|DNA topoisomerase (ATP hydrolyzing) antibody|DNA topoisomerase 2 alpha antibody|DNA topoisomerase 2-alpha antibody|DNA topoisomerase II 170 kD antibody|DNA topoisomerase II alpha isozyme antibody|DNA topoisomerase II antibody|DNA Topoisomerase2 antibody|TOP 2A antibody|TOP2 antibody|TOP2A antibody|TOP2A_HUMAN antibody|Topoisomerase DNA II alpha 170kDa antibody|TP2A antibody|Anti-Topoisomerase II alpha antibody [EP1102Y] (ab52934)
SCBT cat No: sc-16742|sc-240796|sc-130570|sc-390101|sc-135672|sc-292265|sc-393922|sc-30339|sc-30337|sc-130858|sc-1114|sc-28905|sc-10867|



Topo IIalpha (phospho Thr1343) Polyclonal Antibody

Catalogue No.





Phospho-Topo IIalpha (T1343) Polyclonal Antibody detects endogenous levels of Topo IIalpha protein only when phosphorylated at T1343.


Synthesized phospho-peptide derived from Topo IIalpha (phospho Thr1343) at AA range 1280-1360





Recommended dilution

WB 1:500-1:2000; ELISA 1:5000;







Molecular weight

190 kDa


Topo IIalpha (phospho Thr1343) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.


1 mg/ml


Topo IIalpha (phospho Thr1343) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

DNA topoisomerase 2-alpha antibody, DNA topoisomerase II, alpha isozyme antibody

Database links

Human UniProt/Swiss-Prot:P11388;Mouse UniPort/Swiss-Prot: Q01320;Rat UniProt/Swiss-Port: P41516;Human Entrez Gene: 7153;Mouse Entrez Gene: 21973;Rat Entrez Gene: Rn.90996

Protein names

DNA topoisomerase 2-alpha , DNA topoisomerase II, alpha isozyme

Protein function

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity). / ATP-dependent breakage, passage and rejoining of double-stranded DNA. / Mg2+ / Specifically inhibited by the intercalating agent amsacrine.

Protein sequence and domain

The N-terminus has several structural domains; the ATPase domain (about residues 1-265), the transducer domain (about 266-428) and the toprim domain (455-572) (PubMed:25202966). Comparing different structures shows ATP hydrolysis induces domain shifts in the N-terminus that are probably part of the mechanism of DNA cleavage and rejoining (PubMed:25202966). / Belongs to the type II topoisomerase family. / Contains 1 Toprim domain.

Protein post-translational modifications

Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.

Protein cellular localization

Cytoplasm / Nucleus > nucleoplasm

Research area

All research areas>Transcription Regulators>Topo II alpha
(View all antibody categories related to Transcription Regulators)


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St John’s Laboratory Ltd.

Product type

Primary antibody


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