Rabbit Polyclonal Phospho-TPH2 (S19) antibody (STJ90661)

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Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-TPH2 (S19) antibody (STJ90661)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:40000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for TPH2 (phospho Ser19) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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TPH2 antibody, NTPH antibody,|MGC138871 antibody|ADHD7 antibody|FLJ37295 antibody|MGC138872 antibody|Neuronal tryptophan hydroxylase antibody|NTPH antibody|TPH 2 antibody|Tph2 antibody|TPH2_HUMAN antibody|Tryptophan 5-hydroxylase 2 antibody|Tryptophan 5-monooxygenase 2 antibody|Tryptophan hydroxylase 2 antibody|Anti-TPH2 antibody (ab121013)
SCBT cat No: sc-135717|

 

Name

TPH2 (phospho Ser19) Polyclonal Antibody

Catalogue No.

STJ90661

Reactivity

Human, Mouse, Rat

Specificity

Phospho-TPH2 (S19) Polyclonal Antibody detects endogenous levels of TPH2 protein only when phosphorylated at S19.

Immunogen

Synthesized phospho-peptide derived from TPH2 (phospho Ser19) at AA range 1-80

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:40000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

56 kDa

Formulation

TPH2 (phospho Ser19) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

TPH2 (phospho Ser19) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Tryptophan 5-hydroxylase 2 antibody, Neuronal tryptophan hydroxylase antibody, Tryptophan 5-monooxygenase 2 antibody

Database links

Human UniProt/Swiss-Prot:Q8IWU9;Mouse UniPort/Swiss-Prot: Q8CGV2;Rat UniProt/Swiss-Port: Q8CGU9;Human Entrez Gene: 121278;Mouse Entrez Gene: 216343;Rat Entrez Gene: Rn.28510

Protein names

Tryptophan 5-hydroxylase 2 , Neuronal tryptophan hydroxylase , Tryptophan 5-monooxygenase 2

Protein function

L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin. / Fe2+ / 41.3 µM for L-tryptophan / 833 nmol/min/mg enzyme /

Protein tissue specificity

Brain specific.

Involvement in disease

Major depressive disorder (MDD) [MIM:608516]: A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Attention deficit-hyperactivity disorder 7 (ADHD7) [MIM:613003]: A neurobehavioral developmental disorder primarily characterized by the coexistence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.

Protein sequence and domain

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. / Contains 1 ACT domain.

Research area

All research areas>Synthesis and Degradation>TPH
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize TPH2 (phospho Ser19) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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