Rabbit Polyclonal Phospho-TRbeta1 (S142) antibody (STJ90639)

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Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-TRbeta1 (S142) antibody (STJ90639)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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THRB antibody, ERBA2 antibody, NR1A2 antibody, THR1 antibody,|Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2 antibody|C ERBA 2 antibody|C ERBA BETA antibody|c-erbA-2 antibody|c-erbA-beta antibody|ERBA 2 antibody|ERBA BETA antibody|ERBA2 antibody|Erythroblastic leukemia viral (v erb a) oncogene homolog 2 avian antibody|generalized resistance to thyroid hormone antibody|GRTH antibody|MGC126109 antibody|MGC126110 antibody|NR1A2 antibody|Nuclear receptor subfamily 1 group A member 2 antibody|Oncogene ERBA2 antibody|PRTH antibody|THB_HUMAN antibody|THR1 antibody|THRB 1 antibody|THRB 2 antibody|thrB antibody|THRB1 antibody|THRB2 antibody|Thyroid hormone nuclear receptor beta variant 1 antibody|Thyroid hormone receptor beta 1 antibody|Thyroid hormone receptor beta 2 antibody|Thyroid hormone receptor beta antibody|Thyroid hormone receptor, beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2, avian) antibody|Anti-Thyroid Hormone Receptor beta antibody – ChIP Grade (ab5622)
SCBT cat No: To be updated

 

Name

TRbeta1 (phospho Ser142) Polyclonal Antibody

Catalogue No.

STJ90639

Reactivity

Human, Mouse, Rat

Specificity

Phospho-TRbeta1 (S142) Polyclonal Antibody detects endogenous levels of TRbeta1 protein only when phosphorylated at S142.

Immunogen

Synthesized phospho-peptide derived from TRbeta1 (phospho Ser142) at AA range 90-170

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

45 kDa

Formulation

TRbeta1 (phospho Ser142) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

TRbeta1 (phospho Ser142) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Thyroid hormone receptor beta antibody, Nuclear receptor subfamily 1 group A member 2 antibody, c-erbA-2 antibody, c-erbA-beta antibody

Database links

Human UniProt/Swiss-Prot:P10828;Mouse UniPort/Swiss-Prot: P37242;Rat UniProt/Swiss-Port: F1LQ07;Human Entrez Gene: 7068;Mouse Entrez Gene: 21834;Rat Entrez Gene: Rn.34019

Protein names

Thyroid hormone receptor beta , Nuclear receptor subfamily 1 group A member 2 , c-erbA-2 , c-erbA-beta

Protein function

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Involvement in disease

Generalized thyroid hormone resistance (GTHR) [MIM:188570]: A disease characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). . Note: The disease is caused by mutations affecting the gene represented in this entry.; Generalized thyroid hormone resistance autosomal recessive (GTHRAR) [MIM:274300]: An autosomal recessive disorder characterized by goiter, clinical euthyroidism, end-organ unresponsiveness to thyroid hormone, abnormal growth and bone maturation, and deafness. Patients also have high levels of circulating thyroid hormones, with elevated thyroid stimulating hormone. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]: Variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. / Belongs to the nuclear hormone receptor family. NR1 subfamily. / Contains 1 nuclear receptor DNA-binding domain.

Protein cellular localization

Nucleus

Research area

All research areas>Steroid Receptors>TR beta 1
(View all antibody categories related to Steroid Receptors)

Note

AntibodyPlus can customize TRbeta1 (phospho Ser142) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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