Rabbit Polyclonal Phospho-TRF1 (S219) antibody (STJ90560)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-TRF1 (S219) antibody (STJ90560)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for TRF1 (phospho Ser219) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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TERF1 antibody, PIN2 antibody, TRBF1 antibody, TRF antibody, TRF1 antibody,|hTRF1 AS antibody|NIMA interacting protein 2 antibody|NIMA-interacting protein 2 antibody|PIN 2 antibody|PIN2 antibody|t TRF1 antibody|Telomeric protein Pin2 antibody|Telomeric protein Pin2/TRF1 antibody|Telomeric repeat binding factor (NIMA interacting) 1 antibody|Telomeric repeat binding factor 1 antibody|Telomeric repeat binding protein 1 antibody|Telomeric repeat-binding factor 1 antibody|TERF 1 antibody|Terf1 antibody|TERF1_HUMAN antibody|TRBF 1 antibody|TRBF1 antibody|TRF 1 antibody|TRF antibody|TTAGGG repeat binding factor 1 antibody|TTAGGG repeat-binding factor 1 antibody|Anti-TRF1 antibody [TRF-78] (ab10579)
SCBT cat No: To be updated

 

Name

TRF1 (phospho Ser219) Polyclonal Antibody

Catalogue No.

STJ90560

Reactivity

Human, Mouse

Specificity

Phospho-TRF1 (S219) Polyclonal Antibody detects endogenous levels of TRF1 protein only when phosphorylated at S219.

Immunogen

Synthesized phospho-peptide derived from TRF1 (phospho Ser219) at AA range 160-240

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

55 kDa

Formulation

TRF1 (phospho Ser219) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

TRF1 (phospho Ser219) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Telomeric repeat-binding factor 1 antibody, NIMA-interacting protein 2 antibody, TTAGGG repeat-binding factor 1 antibody, Telomeric protein Pin2/TRF1 antibody

Database links

Human UniProt/Swiss-Prot:P54274;Mouse UniPort/Swiss-Prot: P70371;Rat UniProt/Swiss-Port: Q5EB98;Human Entrez Gene: 7013;Mouse Entrez Gene: 21749;Rat Entrez Gene: Rn.33853

Protein names

Telomeric repeat-binding factor 1 , NIMA-interacting protein 2 , TTAGGG repeat-binding factor 1 , Telomeric protein Pin2/TRF1

Protein function

Binds the telomeric double-stranded 5′-TTAGGG-3′ repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5′-TTAGGG-3′ repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.

Protein tissue specificity

Highly expressed and ubiquitous. Isoform Pin2 predominates.

Protein sequence and domain

The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules. / The TRFH dimerization region mediates the interaction with TINF2. / The HTH domain is an independent structural unit and mediates binding to telomeric DNA. / Contains 1 HTH myb-type DNA-binding domain.

Protein post-translational modifications

Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage. / ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA. / Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex, leading to its degradation by the proteasome.

Protein cellular localization

Nucleus / Cytoplasm > cytoskeleton > spindle / Chromosome > telomere

Research area

All research areas>Transcription Regulators>TRF
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize TRF1 (phospho Ser219) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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