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Rabbit Polyclonal Phospho-TRF1 (S219) antibody (STJ90560)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for TRF1 (phospho Ser219) Polyclonal Antibody.
Check alternative names for the antibodyExpand
TERF1 antibody, PIN2 antibody, TRBF1 antibody, TRF antibody, TRF1 antibody,|hTRF1 AS antibody|NIMA interacting protein 2 antibody|NIMA-interacting protein 2 antibody|PIN 2 antibody|PIN2 antibody|t TRF1 antibody|Telomeric protein Pin2 antibody|Telomeric protein Pin2/TRF1 antibody|Telomeric repeat binding factor (NIMA interacting) 1 antibody|Telomeric repeat binding factor 1 antibody|Telomeric repeat binding protein 1 antibody|Telomeric repeat-binding factor 1 antibody|TERF 1 antibody|Terf1 antibody|TERF1_HUMAN antibody|TRBF 1 antibody|TRBF1 antibody|TRF 1 antibody|TRF antibody|TTAGGG repeat binding factor 1 antibody|TTAGGG repeat-binding factor 1 antibody|Anti-TRF1 antibody [TRF-78] (ab10579)
SCBT cat No: To be updated
TRF1 (phospho Ser219) Polyclonal Antibody
|Catalogue No.|| |
Phospho-TRF1 (S219) Polyclonal Antibody detects endogenous levels of TRF1 protein only when phosphorylated at S219.
Synthesized phospho-peptide derived from TRF1 (phospho Ser219) at AA range 160-240
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:5000;
|Molecular weight|| |
TRF1 (phospho Ser219) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
TRF1 (phospho Ser219) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Telomeric repeat-binding factor 1 antibody, NIMA-interacting protein 2 antibody, TTAGGG repeat-binding factor 1 antibody, Telomeric protein Pin2/TRF1 antibody
|Protein names|| |
Telomeric repeat-binding factor 1 , NIMA-interacting protein 2 , TTAGGG repeat-binding factor 1 , Telomeric protein Pin2/TRF1
|Protein function|| |
Binds the telomeric double-stranded 5′-TTAGGG-3′ repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5′-TTAGGG-3′ repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
|Protein tissue specificity|| |
Highly expressed and ubiquitous. Isoform Pin2 predominates.
|Protein sequence and domain|| |
The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules. / The TRFH dimerization region mediates the interaction with TINF2. / The HTH domain is an independent structural unit and mediates binding to telomeric DNA. / Contains 1 HTH myb-type DNA-binding domain.
|Protein post-translational modifications|| |
Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage. / ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA. / Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex, leading to its degradation by the proteasome.
|Protein cellular localization|| |
Nucleus / Cytoplasm > cytoskeleton > spindle / Chromosome > telomere
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St John’s Laboratory Ltd.
|Product type|| |
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