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Rabbit Polyclonal Phospho-Trk C (Y516) antibody (STJ90960)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Trk C (phospho Tyr516) Polyclonal Antibody.
Check alternative names for the antibodyExpand
NTRK3 antibody, TRKC antibody,|BDNF/NT-3 growth factors receptor antibody|Tyrosine kinase receptor A antibody|Tyrosine kinase receptor antibody|Anti-TrkA+B+C antibody [EPR17341] (ab181560)
SCBT cat No: sc-135645|sc-66159|sc-135790|sc-135789|sc-71947|sc-5839|sc-398471|
Trk C (phospho Tyr516) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Trk C (Y516) Polyclonal Antibody detects endogenous levels of Trk C protein only when phosphorylated at Y516.
Synthesized phospho-peptide derived from Trk C (phospho Tyr516) at AA range 460-540
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
Trk C (phospho Tyr516) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Trk C (phospho Tyr516) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
NT-3 growth factor receptor antibody, GP145-TrkC antibody, Trk-C antibody, Neurotrophic tyrosine kinase receptor type 3 antibody, TrkC tyrosine kinase antibody
|Protein names|| |
NT-3 growth factor receptor , GP145-TrkC , Trk-C , Neurotrophic tyrosine kinase receptor type 3 , TrkC tyrosine kinase
|Protein function|| |
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
|Protein tissue specificity|| |
Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
|Involvement in disease|| |
Note: Defects in NTRK3 are associated with susceptibility to congenital heart defects (CHD). A disease characterized by congenital developmental abnormalities involving structures of the heart. CHD are the most common major birth defects and the leading cause of death from congenital malformations. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. / Contains 2 Ig-like C2-type (immunoglobulin-like) domains. / Contains 2 LRR (leucine-rich) repeats. / Contains 1 LRRCT domain. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
|Protein cellular localization|| |
Membrane; Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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