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Rabbit Polyclonal Phospho-Troponin I-C (S43) antibody (STJ90883)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
Recommended protocols: check protocols
Click or hover above images to see image description for Troponin I-C (phospho Ser43) Polyclonal Antibody.
Check alternative names for the antibodyExpand
TNNI3 antibody, TNNC1 antibody,|cardiac muscle antibody|Cardiac troponin I antibody|cardiomyopathy, dilated 2A (autosomal recessive) antibody|Cardiomyopathy, familial hypertrophic, 7, included antibody|CMD1FF antibody|CMD2A antibody|CMH7 antibody|cTnI antibody|Familial hypertrophic cardiomyopathy 7 antibody|MGC116817 antibody|RCM1 antibody|Tn1 antibody|Tni antibody|TNN I3 antibody|TNNC 1 antibody|TNNC1 antibody|TNNI3 antibody|TNNI3_HUMAN antibody|Troponin I antibody|Troponin I cardiac antibody|Troponin I cardiac muscle antibody|Troponin I cardiac muscle isoform antibody|Troponin I type 3 cardiac antibody|troponin I, cardiac 3 antibody|TroponinI antibody|Ttroponin I type 3 (cardiac) antibody|Anti-Cardiac Troponin I antibody (ab47003)
SCBT cat No: sc-66159|sc-135790|sc-135789|sc-71947|sc-5839|sc-398471|sc-56207|sc-376454|sc-22772|sc-514984|sc-56461|sc-5842|sc-293149|sc-32838|sc-32839|sc-130609|sc-373951|
Troponin I-C (phospho Ser43) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Troponin I-C (S43) Polyclonal Antibody detects endogenous levels of Troponin I-C protein only when phosphorylated at S43.
Synthesized phospho-peptide derived from Troponin I-C (phospho Ser43) at AA range 30-110
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
|Molecular weight|| |
Troponin I-C (phospho Ser43) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Troponin I-C (phospho Ser43) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Troponin I, cardiac muscle antibody, Cardiac troponin I antibody
|Protein names|| |
Troponin I, cardiac muscle , Cardiac troponin I
|Protein function|| |
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
|Involvement in disease|| |
Cardiomyopathy, familial hypertrophic 7 (CMH7) [MIM:613690]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Cardiomyopathy, familial restrictive 1 (RCM1) [MIM:115210]: A heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Cardiomyopathy, dilated 2A (CMD2A) [MIM:611880]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Cardiomyopathy, dilated 1FF (CMD1FF) [MIM:613286]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the troponin I family.
|Protein post-translational modifications|| |
Phosphorylated at Ser-42 and Ser-44 by PRKCE; phosphorylation increases myocardium contractile dysfunction (By similarity). Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).
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St John’s Laboratory Ltd.
|Product type|| |
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