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Rabbit Polyclonal Phospho-Tuberin (S939) antibody (STJ90836)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Tuberin (phospho Ser939) Polyclonal Antibody.
Check alternative names for the antibodyExpand
TSC2 antibody, TSC4 antibody,|FLJ43106 antibody|LAM antibody|OTTHUMP00000158940 antibody|OTTHUMP00000198394 antibody|OTTHUMP00000198395 antibody|PPP1R160 antibody|Protein phosphatase 1, regulatory subunit 160 antibody|tsc2 antibody|TSC2_HUMAN antibody|TSC4 antibody|TSC4 gene, formerly antibody|TSC4, formerly antibody|Tuberin antibody|Tuberous sclerosis 2 antibody|Tuberous sclerosis 2 protein antibody|Tuberous sclerosis 2 protein homolog antibody|Anti-Tuberin antibody [Y320] (ab32554)
SCBT cat No: sc-293149|sc-32838|sc-32839|sc-130609|sc-373951|sc-32866|sc-135637|sc-11763|
Tuberin (phospho Ser939) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Tuberin (S939) Polyclonal Antibody detects endogenous levels of Tuberin protein only when phosphorylated at S939.
Synthesized phospho-peptide derived from Tuberin (phospho Ser939) at AA range 880-960
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
Tuberin (phospho Ser939) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tuberin (phospho Ser939) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tuberin antibody, Tuberous sclerosis 2 protein antibody
|Protein names|| |
Tuberin , Tuberous sclerosis 2 protein
|Protein function|| |
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
|Protein tissue specificity|| |
Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.
|Involvement in disease|| |
Tuberous sclerosis 2 (TSC2) [MIM:613254]: An autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. It is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (developmental abnormalities of tissue combination). Clinical manifestations include epilepsy, learning difficulties, behavioral problems, and skin lesions. Seizures can be intractable and premature death can occur from a variety of disease-associated causes. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Lymphangioleiomyomatosis (LAM) [MIM:606690]: Progressive and often fatal lung disease characterized by a diffuse proliferation of abnormal smooth muscle cells in the lungs. It affects almost exclusively young women and can occur as an isolated disorder or in association with tuberous sclerosis complex. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 1 Rap-GAP domain.
|Protein post-translational modifications|| |
Phosphorylation at Ser-1387, Ser-1418 or Ser-1420 does not affect interaction with TSC1. Phosphorylation at Ser-939 and Thr-1462 by PKB/AKT1 is induced by growth factor stimulation. Phosphorylation by AMPK activates it and leads to negatively regulates the mTORC1 complex. Phosphorylated at Ser-1798 by RPS6KA1; phosphorylation inhibits TSC2 ability to suppress mTORC1 signaling. Phosphorylated by DAPK1. / Ubiquitinated by the DCX(FBXW5) E3 ubiquitin-protein ligase complex, leading to its subsequent degradation. Ubiquitinated by MYCBP2 independently of its phosphorylation status leading to subsequent degradation; association with TSC1 protects from ubiquitination.
|Protein cellular localization|| |
Cytoplasm / Membrane; Peripheral membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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