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Rabbit Polyclonal Phospho-VAV1-Y174 antibody (AP0180)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal Phospho-VAV1-Y174 antibody.
Check alternative names for the antibodyExpand
Oncogene vav antibody|p95Vav antibody|Proto-oncogene vav antibody|Protooncogene vav antibody|VAV 1 antibody|VAV 1 oncogene antibody|VAV antibody|Vav proto oncogene antibody|VAV_HUMAN antibody|VAV1 antibody|Phospho anti-VAV1 (Y174) antibody [EP510Y] (ab76225)
SCBT cat No: sc-135785|sc-135787|sc-135786|sc-135788|sc-16408|sc-16409|sc-16673|sc-12973|sc-16674|sc-248328|sc-248326|
Rabbit Polyclonal Phospho-VAV1-Y174 antibody
|Catalogue No.|| |
Human, Mouse, Rat
A phospho specific peptide corresponding to residues surrounding Y174 of human VAV1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Phospho-VAV1-Y174 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/P15498">P15498</a>
|Protein names|| |
|Protein function|| |
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
|Protein tissue specificity|| |
Widely expressed in hematopoietic cells but not in other cell types.
|Protein sequence and domain|| |
Contains 1 CH (calponin-homology) domain.; Contains 1 DH (DBL-homology) domain.; Contains 1 PH domain.; Contains 1 phorbol-ester/DAG-type zinc finger.; Contains 1 SH2 domain.; Contains 2 SH3 domains. The DH domain is involved in interaction with CCPG1.
|Protein post-translational modifications|| |
Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity). Phosphorylated by FYN.
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/GDPGTP-Binding-Proteins/">GDP/GTP Binding Proteins</a>><a href="http://antibodyplus.com/product-tag/Vav/">Vav</a><br><a href="http://antibodyplus.com/product-tag/GDPGTP-Binding-Proteins/"> (View all antibody categories related to GDP/GTP Binding Proteins)</a>
AntibodyPlus can customize Phospho-VAV1-Y174 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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