Rabbit Polyclonal Phospho-VAV1-Y174 antibody (AP0180)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-VAV1-Y174 antibody (AP0180)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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VAV antibody;
Oncogene vav antibody|p95Vav antibody|Proto-oncogene vav antibody|Protooncogene vav antibody|VAV 1 antibody|VAV 1 oncogene antibody|VAV antibody|Vav proto oncogene antibody|VAV_HUMAN antibody|VAV1 antibody|Phospho anti-VAV1 (Y174) antibody [EP510Y] (ab76225)

SCBT cat No: sc-135785|sc-135787|sc-135786|sc-135788|sc-16408|sc-16409|sc-16673|sc-12973|sc-16674|sc-248328|sc-248326|

Name

Rabbit Polyclonal Phospho-VAV1-Y174 antibody

Catalogue No.

AP0180

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding Y174 of human VAV1

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

95kDa

Formulation

Phospho-VAV1-Y174 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

VAV antibody;

Protein names

VAV;

Protein function

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Protein tissue specificity

Widely expressed in hematopoietic cells but not in other cell types.

Protein sequence and domain

Contains 1 CH (calponin-homology) domain.; Contains 1 DH (DBL-homology) domain.; Contains 1 PH domain.; Contains 1 phorbol-ester/DAG-type zinc finger.; Contains 1 SH2 domain.; Contains 2 SH3 domains. The DH domain is involved in interaction with CCPG1.

Protein post-translational modifications

Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity). Phosphorylated by FYN.

Background

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/GDPGTP-Binding-Proteins/">GDP/GTP Binding Proteins</a>><a href="http://antibodyplus.com/product-tag/Vav/">Vav</a><br><a href="http://antibodyplus.com/product-tag/GDPGTP-Binding-Proteins/"&gt; (View all antibody categories related to GDP/GTP Binding Proteins)</a>

Note

AntibodyPlus can customize Phospho-VAV1-Y174 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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