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Rabbit Polyclonal Phospho-Vav3 (Y173) antibody (STJ90999)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
Recommended protocols: check protocols
Click or hover above images to see image description for Vav3 (phospho Tyr173) Polyclonal Antibody.
Check alternative names for the antibodyExpand
VAV3 antibody,|FLJ40431 antibody|Guanine nucleotide exchange factor VAV3 antibody|Protein vav 3 antibody|Protein vav3 antibody|RGD1565941 antibody|VAV 3 antibody|Vav 3 guanine nucleotide exchange factor antibody|VAV 3 oncogene antibody|VAV 3 protein antibody|VAV-3 antibody|Vav3 antibody|VAV3 oncogene antibody|VAV3 protein antibody|VAV3_HUMAN antibody|Anti-VAV3 antibody [EP1130Y] (ab52938)
SCBT cat No: To be updated
Vav3 (phospho Tyr173) Polyclonal Antibody
|Catalogue No.|| |
Phospho-Vav3 (Y173) Polyclonal Antibody detects endogenous levels of Vav3 protein only when phosphorylated at Y173.
Synthesized phospho-peptide derived from Vav3 (phospho Tyr173) at AA range 110-190
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
|Molecular weight|| |
Vav3 (phospho Tyr173) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Vav3 (phospho Tyr173) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Guanine nucleotide exchange factor VAV3 antibody, VAV-3 antibody
|Protein names|| |
Guanine nucleotide exchange factor VAV3 , VAV-3
|Protein function|| |
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).
|Protein tissue specificity|| |
Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable.
|Protein sequence and domain|| |
Contains 1 CH (calponin-homology) domain. / Contains 1 DH (DBL-homology) domain. / Contains 1 PH domain. / Contains 1 phorbol-ester/DAG-type zinc finger. / Contains 1 SH2 domain. / Contains 2 SH3 domains.
|Protein post-translational modifications|| |
Phosphorylated. Phosphorylation can be mediated by ROS1. In osteoclasts, undergoes tyrosine phosphorylation in response to CSF1 (By similarity).
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St John’s Laboratory Ltd.
|Product type|| |
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