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Rabbit Polyclonal Phospho-WASP (Y290) antibody (STJ90839)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for WASP (phospho Tyr290) Polyclonal Antibody.
Check alternative names for the antibodyExpand
WAS antibody, IMD2 antibody,|Eczema thrombocytopenia antibody|IMD2 antibody|SCNX antibody|THC antibody|THC1 antibody|Thrombocytopenia 1 (X linked) antibody|U42471 antibody|Was antibody|WASp antibody|WASP_HUMAN antibody|Wiskott Aldrich syndrome (eczema thrombocytopenia) antibody|Wiskott Aldrich syndrome antibody|Wiskott Aldrich syndrome protein antibody|Wiskott-Aldrich syndrome protein antibody|Anti-WASP antibody [EP2541Y] (ab75830)
SCBT cat No: To be updated
WASP (phospho Tyr290) Polyclonal Antibody
|Catalogue No.|| |
Phospho-WASP (Y290) Polyclonal Antibody detects endogenous levels of WASP protein only when phosphorylated at Y290.
Synthesized phospho-peptide derived from WASP (phospho Tyr290) at AA range 230-310
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
WASP (phospho Tyr290) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
WASP (phospho Tyr290) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Wiskott-Aldrich syndrome protein antibody, WASp antibody
|Protein names|| |
Wiskott-Aldrich syndrome protein , WASp
|Protein function|| |
Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria.
|Protein tissue specificity|| |
Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen.
|Involvement in disease|| |
Wiskott-Aldrich syndrome (WAS) [MIM:301000]: An X-linked recessive immunodeficiency characterized by eczema, thrombocytopenia, recurrent infections, and bloody diarrhea. Death usually occurs before age 10. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Thrombocytopenia 1 (THC1) [MIM:313900]: Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Neutropenia, severe congenital, X-linked (XLN) [MIM:300299]: A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The WH1 (Wasp homology 1) domain may bind a Pro-rich ligand. / The CRIB (Cdc42/Rac-interactive-binding) region binds to the C-terminal WH2 domain in the autoinhibited state of the protein. Binding of Rho-type GTPases to the CRIB induces a conformation change and leads to activation. / Contains 1 CRIB domain. / Contains 1 WH1 domain. / Contains 1 WH2 domain.
|Protein post-translational modifications|| |
Phosphorylated at Tyr-291 by FYN and HCK, inducing WAS effector activity after TCR engagement. Phosphorylation at Tyr-291 enhances WAS activity in promoting actin polymerization and filopodia formation.
|Protein cellular localization|| |
Cytoplasm > cytoskeleton
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St John’s Laboratory Ltd.
|Product type|| |
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