Rabbit Polyclonal Phospho-WASP (Y290) antibody (STJ90839)

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Reactivity: Human, Mouse
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-WASP (Y290) antibody (STJ90839)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for WASP (phospho Tyr290) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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WAS antibody, IMD2 antibody,|Eczema thrombocytopenia antibody|IMD2 antibody|SCNX antibody|THC antibody|THC1 antibody|Thrombocytopenia 1 (X linked) antibody|U42471 antibody|Was antibody|WASp antibody|WASP_HUMAN antibody|Wiskott Aldrich syndrome (eczema thrombocytopenia) antibody|Wiskott Aldrich syndrome antibody|Wiskott Aldrich syndrome protein antibody|Wiskott-Aldrich syndrome protein antibody|Anti-WASP antibody [EP2541Y] (ab75830)
SCBT cat No: To be updated

 

Name

WASP (phospho Tyr290) Polyclonal Antibody

Catalogue No.

STJ90839

Reactivity

Human, Mouse

Specificity

Phospho-WASP (Y290) Polyclonal Antibody detects endogenous levels of WASP protein only when phosphorylated at Y290.

Immunogen

Synthesized phospho-peptide derived from WASP (phospho Tyr290) at AA range 230-310

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

60 kDa

Formulation

WASP (phospho Tyr290) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

WASP (phospho Tyr290) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Wiskott-Aldrich syndrome protein antibody, WASp antibody

Database links

Human UniProt/Swiss-Prot:P42768;Mouse UniPort/Swiss-Prot: P70315;Rat UniProt/Swiss-Port: G3V9K5;Human Entrez Gene: 7454;Mouse Entrez Gene: 22376;Rat Entrez Gene: Rn.207069

Protein names

Wiskott-Aldrich syndrome protein , WASp

Protein function

Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria.

Protein tissue specificity

Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen.

Involvement in disease

Wiskott-Aldrich syndrome (WAS) [MIM:301000]: An X-linked recessive immunodeficiency characterized by eczema, thrombocytopenia, recurrent infections, and bloody diarrhea. Death usually occurs before age 10. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Thrombocytopenia 1 (THC1) [MIM:313900]: Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Neutropenia, severe congenital, X-linked (XLN) [MIM:300299]: A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

The WH1 (Wasp homology 1) domain may bind a Pro-rich ligand. / The CRIB (Cdc42/Rac-interactive-binding) region binds to the C-terminal WH2 domain in the autoinhibited state of the protein. Binding of Rho-type GTPases to the CRIB induces a conformation change and leads to activation. / Contains 1 CRIB domain. / Contains 1 WH1 domain. / Contains 1 WH2 domain.

Protein post-translational modifications

Phosphorylated at Tyr-291 by FYN and HCK, inducing WAS effector activity after TCR engagement. Phosphorylation at Tyr-291 enhances WAS activity in promoting actin polymerization and filopodia formation.

Protein cellular localization

Cytoplasm > cytoskeleton

Research area

All research areas>Structural Proteins>WASP
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus can customize WASP (phospho Tyr290) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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